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Gene Information
Gene symbol: MAP2K4
Gene name: mitogen-activated protein kinase kinase 4
HGNC ID: 6844
Synonyms: MEK4, JNKK1, PRKMK4, MKK4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAP3K1 | 1 hits |
| 2 | MAPK1 | 1 hits |
| 3 | MAPK8 | 1 hits |
| 4 | MAPK8IP1 | 1 hits |
| 5 | MAPK9 | 1 hits |
| 6 | NFKB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19243309 | Its partner, JIP1 (JNK-interacting protein 1), serves a scaffolding function that facilitates JNK1 activation by MKK4 [MAPK (mitogen-activated protein kinase) kinase 4] and MKK7 (MAPK kinase 7). |
| 2 | 7997269 | SEK1 is a potent activator of the SAPKs in vitro and in vivo. |
| 3 | 7997269 | An inactive SEK1 mutant blocks SAPK activation by extracellular stimuli without interfering with the MAPK pathway. |
| 4 | 7997269 | Although alternative mechanisms of SAPK activation may exist, as an immediate upstream activator of the SAPKs, SEK1 further defines a signalling cascade that couples cellular stress agonists to the c-Jun transcription factor. |
| 5 | 18420486 | Downregulation of MEKK-1 in human islet cells provoked opposite effects, i.e., attenuation of cytokine-induced JNK and MKK4 activation, IkappaB stability, and a less pronounced NF-kappaB translocation. betaTC-6 cells with a downregulated MEKK-1 expression displayed also a weaker cytokine-induced iNOS expression and lower cell death rates. |