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Gene Information
Gene symbol: MAP3K1
Gene name: mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
HGNC ID: 6848
Synonyms: MEKK, MAPKKK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | KLRG1 | 1 hits |
| 3 | MAP2K4 | 1 hits |
| 4 | MAP4K2 | 1 hits |
| 5 | MAPK8 | 1 hits |
| 6 | TCEAL1 | 1 hits |
| 7 | TNF | 1 hits |
| 8 | TRAF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17583797 | In the present study the effect of these cytokines and mitogen-activated protein kinase kinase kinase 1 (MEKK1), which is known to be activated by these cytokines, on human insulin gene (INS) transcription was investigated. |
| 2 | 17583797 | We found here that MafA transcription activity is markedly inhibited by MEKK1 and IL-1beta. |
| 3 | 17583797 | These data suggest that IL-1beta through MEKK1 inhibits INS transcription and does so, at least in part, by decreasing MafA transcriptional activity at the RIPE3b control element. |
| 4 | 17583797 | Since inappropriate insulin biosynthesis contributes to beta cell dysfunction, inhibition of MEKK1 might decelerate or prevent progression from a prediabetic state to diabetes mellitus. |
| 5 | 11784851 | Recombinant forms of MAP3K MEK kinase 1 (MEKK1) interact in vivo and in vitro with the STE20 protein homologue germinal center kinase (GCK), and both GCK and MEKK1 associate in vivo with the adapter protein tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2). |
| 6 | 11784851 | In addition, we have developed an in vitro assay system with which we demonstrate that purified, active GCK and TRAF2 activate MEKK1. |
| 7 | 11784851 | The RING domain of TRAF2 is necessary for optimal in vitro activation of MEKK1, but the kinase domain of GCK is not. |
| 8 | 12647305 | These results suggested that the alteration of intracellular milieu induced by MG through a MEKK1-mediated and PI3K/PKC/Raf-1-independent pathway resulted in the modification of cell response to IGF-I for p21(Waf1/Cip1)-mediated growth arrest, which may be one of the crucial mechanisms for MG to promote the development of chronic clinical complications in diabetes. |
| 9 | 18420486 | We observed that overexpression of wild-type MEKK-1, but not of a kinase dead MEKK-1 mutant, resulted in potentiation of cytokine-induced JNK activation, inhibitor of kappaB (IkappaB) degradation, and cell death. |
| 10 | 18420486 | Downregulation of MEKK-1 in human islet cells provoked opposite effects, i.e., attenuation of cytokine-induced JNK and MKK4 activation, IkappaB stability, and a less pronounced NF-kappaB translocation. betaTC-6 cells with a downregulated MEKK-1 expression displayed also a weaker cytokine-induced iNOS expression and lower cell death rates. |