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Gene Information
Gene symbol: MAP3K8
Gene name: mitogen-activated protein kinase kinase kinase 8
HGNC ID: 6860
Synonyms: Tpl-2, EST, c-COT, MEKK8
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | IL1B | 1 hits |
| 2 | INS | 1 hits |
| 3 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21346175 | Male TPL2KO and wild-type (WT) littermates were fed a low-fat diet or a high-fat diet to investigate the effect of TPL2 deletion on obesity, inflammation, and insulin sensitivity. |
| 2 | 19808894 | We show that the MAP3K8 called Tpl2 was expressed in adipocytes and that IL-1beta and TNF-alpha activated Tpl2 and regulated its expression through an IKKbeta pathway. |
| 3 | 19808894 | Tpl2 mRNA expression was upregulated in adipose tissue of obese mice and patients and correlated with TNF-alpha expression. |