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Gene Information
Gene symbol: MAP4K2
Gene name: mitogen-activated protein kinase kinase kinase kinase 2
HGNC ID: 6864
Synonyms: GCK, BL44
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAP3K1 | 1 hits |
| 2 | MAPK9 | 1 hits |
| 3 | STK24 | 1 hits |
| 4 | TRAF2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7477268 | Here we report specific activation of the mammalian stress-activated protein kinase (SAPK) pathway by germinal centre kinase (GCK), a human STE20 homologue. |
| 2 | 7477268 | Activation of the SAPK pathway by GCK illustrates further the striking conservation of eukaryotic signalling mechanisms and defines the first physiological function of a mammalian Ste20. |
| 3 | 11784851 | Recombinant forms of MAP3K MEK kinase 1 (MEKK1) interact in vivo and in vitro with the STE20 protein homologue germinal center kinase (GCK), and both GCK and MEKK1 associate in vivo with the adapter protein tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2). |
| 4 | 11784851 | In addition, we have developed an in vitro assay system with which we demonstrate that purified, active GCK and TRAF2 activate MEKK1. |
| 5 | 11784851 | The RING domain of TRAF2 is necessary for optimal in vitro activation of MEKK1, but the kinase domain of GCK is not. |