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Gene Information
Gene symbol: MAPK7
Gene name: mitogen-activated protein kinase 7
HGNC ID: 6880
Synonyms: BMK1, ERK5
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EDN1 | 1 hits |
| 2 | GGH | 1 hits |
| 3 | KLF2 | 1 hits |
| 4 | MAP2K5 | 1 hits |
| 5 | MEF2C | 1 hits |
| 6 | NOS3 | 1 hits |
| 7 | PIAS1 | 1 hits |
| 8 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18218985 | We investigated whether H(2)O(2) and AGE (advanced glycation end products), 2 well-known mediators of diabetes, negatively regulated ERK5 transcriptional activity and laminar flow-induced endothelial nitric oxide synthase expression through ERK5 SUMOylation. |
| 2 | 18218985 | ERK5 transcriptional activity, but not kinase activity, was inhibited by expression of Ubc9 (SUMO E2 conjugase) or PIAS1 (E3 ligase), suggesting the involvement of ERK5 SUMOylation on its transcriptional activity. |
| 3 | 18467627 | ERK5 wild-type transcriptional activity was inhibited by Ubc9 (SUMO E2 conjugase) or PIAS1 (E3 ligase), but not in the ERK5-SUMOylation-site defective mutant (K6R/K22R). |
| 4 | 20628425 | Furthermore, 1 month of diabetes caused a significant increase in retinal ET-1 mRNA and decrease in ERK5 mRNA expression. |
| 5 | 20671964 | In HMVECs, glucose caused initial activation followed by deactivation of ERK5 and its downstream mediators myocyte enhancing factor 2C (MEF2C) and Kruppel-like factor 2 (KLF2) mRNA expression. |
| 6 | 20671964 | Furthermore, siRNA mediated ERK5 gene knockdown suppressed MEF2C and KLF2 expression and increased VEGF expression and angiogenesis. |
| 7 | 20671964 | On the other hand, constitutively active MEK5, an activator of ERK5, increased ERK5 activation and ERK5 and KLF2 mRNA expression and attenuated basal- and glucose-induced VEGF mRNA expression. |
| 8 | 20671964 | These results indicated that ERK5 depletion contributes to glucose induced increased VEGF production and angiogenesis. |
| 9 | 15086914 | Finally, transfection of dominant-negative MEK5, which is an upstream regulator of BMK1, abolished the BMK1-mediated rat mesangial cell proliferation stimulated by high glucose. |