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Gene Information
Gene symbol: MAPK8IP1
Gene name: mitogen-activated protein kinase 8 interacting protein 1
HGNC ID: 6882
Synonyms: IB1, JIP-1, JIP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CASP3 | 1 hits |
| 2 | HNF1A | 1 hits |
| 3 | MAP2K4 | 1 hits |
| 4 | MAP2K7 | 1 hits |
| 5 | MAPK1 | 1 hits |
| 6 | MAPK8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12683939 | The effects of JNK activation on apoptosis were demonstrated by the observations that (i). its inhibition by dicumarol prevented caspase-3 activation and apoptosis, (ii). adenoviral expression of the JNK-interacting scaffold protein JIP-1/IB-1 increased AICA-riboside-induced JNK activation and apoptosis. |
| 2 | 18252896 | In fact, ex-4 as well as IBMX and forskolin induced expression of IB1 at the promoter level through cAMP response element binding transcription factor 1. |
| 3 | 18252896 | The data establish the requirement of IB1 in the protective action of ex-4 against apoptosis elicited by IL-1 beta and highlight the GLP-1 mimetics as new potent inhibitors of the JNK signaling induced by cytokines. |
| 4 | 19243309 | Its partner, JIP1 (JNK-interacting protein 1), serves a scaffolding function that facilitates JNK1 activation by MKK4 [MAPK (mitogen-activated protein kinase) kinase 4] and MKK7 (MAPK kinase 7). |
| 5 | 19243309 | For example, reduced insulin resistance and JNK activation are observed in JIP1-deficient mice. |