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Gene Information
Gene symbol: MARK2
Gene name: MAP/microtubule affinity-regulating kinase 2
HGNC ID: 3332
Synonyms: PAR-1, Par1b
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A1 | 1 hits |
| 2 | F2 | 1 hits |
| 3 | MYL6B | 1 hits |
| 4 | RHOA | 1 hits |
| 5 | RHOD | 1 hits |
| 6 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11919159 | However, inhibition of the endogenous small GTPase RhoA by the C3 exoenzyme, dominant-negative N19-RhoA, activated G26V-RhoD, and activators of the nitric oxide/cGMP pathways conferred invasive activity to PAR-1 via a signaling cascade using Galphaq, phospholipase C (PLC), Ca(2+)/calmodulin myosin light chain kinase (CaM-MLCK), and phosphorylation of MLC. |
| 2 | 11919159 | We conclude that dynamic regulation of Rho GTPases activation and inactivation by oncogenes, growth factors, cGMP-inducing agents, and adhesion molecules can initiate convergent invasion signals controlled by the thrombin PAR-1 in cancer cells. |
| 3 | 11919159 | RhoA- and RhoD-dependent regulatory switch of Galpha subunit signaling by PAR-1 receptors in cellular invasion. |
| 4 | 15968399 | The P2Y(12) receptors also mediated the potentiating effect of PAR-1 stimulation on thrombin generation. |
| 5 | 16021635 | Because we found that hIPCs, PANC-1 cells, human fetal pancreas, and human adult islets express two protease-activated receptors (PARs), PAR-1 and PAR-2, we tested whether the effects of thrombin and trypsin were mediated, at least in part, by these receptors. |
| 6 | 17530178 | In contrast, platelet aggregation induced by collagen or ADP, CD31, CD41, CD42b, CD51/61, CD62p, CD63, CD154, CD165, so as formation of platelet-monocyte aggregates, PAR-1 thrombin receptor, and thrombospondin did not differ between groups. |
| 7 | 18571697 | The effect of thrombin was not mimicked by the catalytically inactive FPRCK-HCT and was blocked in a concentration- dependent manner by the PAR-1 antagonist, JNJ5177049. |
| 8 | 21164077 | High glucose pretreatment (48 hours) enhanced thrombin or PAR-4-activating peptide but not PAR-1-activating peptide evoked intracellular calcium mobilization, migration, and tumor necrosis factor ? gene expression. |
| 9 | 21756365 | The simulated effects of PAR-1, Rho GTPase, ROCK, VEGF and VEGFR2 over-expression on MLC activation, and the collective modulation by thrombin and histamine are consistent with experimental findings. |