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Gene Information
Gene symbol: MCL1
Gene name: myeloid cell leukemia sequence 1 (BCL2-related)
HGNC ID: 6943
Synonyms: BCL2L3, Mcl-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AKT1 | 1 hits |
| 3 | BCL2 | 1 hits |
| 4 | BCL2L1 | 1 hits |
| 5 | BCL2L11 | 1 hits |
| 6 | CASP3 | 1 hits |
| 7 | CYCS | 1 hits |
| 8 | INS | 1 hits |
| 9 | LEP | 1 hits |
| 10 | SAT1 | 1 hits |
| 11 | SMAD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21143387 | In cardiomyocytes, CM from EAT of HFD-fed animals increased SMAD2-phosphorylation, a marker for activin A-signalling, decreased sarcoplasmic-endoplasmic reticulum calcium ATPase 2a expression, and reduced insulin-mediated phosphorylation of Akt-Ser473 versus CM from SAT and standard diet-fed animals. |
| 2 | 21498926 | Adiponectin gene expression in EAT and PAT were significantly lower in MS group compared to the control group (p<0.0001, p=0.04, respectively) while SAT adiponectin gene expression did not differ significantly (p=0.64). |
| 3 | 21498926 | TNF-? and leptin gene expressions were found to be statistically significantly higher in EAT, PAT and SAT of the MS group (p<0.0001, for all). |
| 4 | 21498926 | Our results demonstrate that TNF-? and leptin gene expressions increase prominently in the EAT, PAT and SAT while adiponectin gene expression decreases significantly in EAT and PAT in MS patients with CAD. |
| 5 | 21498926 | These findings suggest that disturbances in expression of adiponectin, TNF-? and leptin in EAT, PAT and SAT might play an important role in MS patients with CAD. |
| 6 | 20798690 | All cytotoxic stresses rapidly and preferentially decreased Mcl-1 protein expression as compared with the late effect observed on the other antiapoptotic proteins, Bcl-2 and Bcl-xL. |
| 7 | 20798690 | Knocking down Mcl-1 using small interference RNAs increased apoptosis and caspase-3 cleavage induced by cytokines, palmitate or thapsigargin, whereas Mcl-1 overexpression partly prevented Bax translocation to the mitochondria, cytochrome c release, caspase-3 cleavage and apoptosis induced by the ?-cell death effectors. |
| 8 | 21977009 | Indeed, Bim knockdown prevented both dsRNA- and Coxsackievirus B5-induced beta cell death, and counteracted the proapoptotic effects of Mcl-1 silencing. |