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Gene Information
Gene symbol: METAP2
Gene name: methionyl aminopeptidase 2
HGNC ID: 16672
Synonyms: MNPEP, p67, MAP2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | MAPK1 | 1 hits |
| 2 | MYB | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21937698 | Zebrafish metap2 was expressed ubiquitously during early embryogenesis and later in the somitic region, the caudal hematopoietic tissue, and pronephric duct. metap2 was inhibited by morpholino and fumagillin treatment, resulting in increased mpo expression at 18 hours postfertilization and reduced c-myb expression along the ventral wall of dorsal aorta at 36 hours postfertilization. |
| 2 | 21937698 | Inhibition of MetAP2 in CB CD34(+) cells by fumagillin had no effect on overall clonogenic activity but significantly reduced their engraftment into immunodeficient nonobese diabetes/severe combined immunodeficiency mice. metap2 knock-down in zebrafish and inhibition by fumagillin in zebrafish and human CB CD34(+) cells inhibited Calmodulin Kinase II activity and induced ERK phosphorylation. |
| 3 | 21937698 | This study demonstrated a hithertoundescribed role of MetAP2 in definitive hematopoiesis and a possible link to noncanonical Wnt and ERK signaling. |