Ignet

Gene Information

Gene symbol: MIF

Gene name: macrophage migration inhibitory factor (glycosylation-inhibiting factor)

HGNC ID: 7097

Synonyms: GIF

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	ALB	1 hits
3	APLP2	1 hits
4	C5AR1	1 hits
5	CFD	1 hits
6	EIF1	1 hits
7	FAS	1 hits
8	FOS	1 hits
9	GPR77	1 hits
10	IFNG	1 hits
11	IL10	1 hits
12	IL13	1 hits
13	INS	1 hits
14	JUN	1 hits
15	MAPK8	1 hits
16	PPARA	1 hits
17	SUCLA2	1 hits
18	TLR4	1 hits
19	TNF	1 hits
20	TNFRSF11B	1 hits
21	TNFSF10	1 hits

Related Sentences

#	PMID	Sentence
1	15286457	On the other hand, the macrophage migration inhibitory factor (MIF) is a cytokine with multiple biological activities, including the ability to act as potent amyloid beta (A-beta)-binding protein.
2	15850715	Long chain polyunsaturated fatty acids (LCPUFAs) increase cell membrane fluidity and enhance the number of insulin receptors and the affinity of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of GLUT-4 receptors, serve as endogenous ligands of PPARs, modify lipolysis, and regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.
3	15790730	Neutralization of MIF also down-regulated the ex vivo secretion of the proinflammatory mediators, TNF-alpha, interferon-gamma, and nitric oxide, while augmenting that of the antiinflammatory cytokine, IL-10.
4	19020281	These data show that functional C5a receptors (C5a and C5L2) are present in the anterior pituitary gland and they may play a role in dampening down inflammation by inhibiting the release of MIF and stimulating the release of ACTH.
5	19240767	Inflammatory cytokines, including MIF via CD74, upregulate TRAIL.
6	19506561	MIF was the only gene whose expression in both freshly isolated adipocytes and cultured preadipocytes was positively associated with adipocytes diameter and negatively associated with peripheral and hepatic insulin action (all P<0.05).
7	19506561	The mRNA expression concentrations of the MIF gene in adipocytes were not associated with plasma concentrations of MIF, but were negatively associated with plasma adiponectin concentrations (P=0.004).
8	20703212	The expression of TNF-related apoptosis-inducing ligand (TRAIL), its decoy receptor osteoprotegerin, and receptors Fas (a Fas ligand receptor) and CD74 (a migration inhibitory factor (MIF) receptor) were induced in human diabetic nephropathy.
9	20693579	Additionally, attempts to elucidate a possible mechanism underlying the UVA-mediated effects revealed that UVA induced migration inhibitory factor (MIF) gene expression, and this was mediated through activation of AP-1 (especially JNK and p42/44 MAPK) and nuclear factor-?B.
10	20573157	In addition, AC16 cells were pretreated with 2.5 ?mol/L SP600125 (a JNK inhibitor), 40 ?mol/L (s,r)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester (ISO-1; an MIF antagonist) or 0.1% dimethylsulphoxide (DMSO; vehicle) for 1 h prior to exposure to 25 mmol/L glucose and culture for 72 h, followed by annexin V-fluorescein isothiocyanate/propidium iodide staining and flow cytometry analysis.
11	20573157	Furthermore, JNK phosphorylation was attenuated by inhibition of endogenous MIF. 4.
12	21094094	Before transplantation, high IL-13 and IL-18 concentrations were prospectively associated for subsequent loss of graft function in IAK recipients, whereas in SIK recipients, high macrophage migration inhibitory factor (MIF) concentrations were associated with subsequent loss of graft function.
13	20380658	AT expressions of ADN and macrophage migration inhibiting factor (MMIF), IL18 and cluster of differentiation factor 14 (CD14) in both depots showed inverse correlations.
14	21215754	Expression of toll-like receptor-4 (TLR-4), phosphorylation of c-Jun N-terminal kinase (JNK), and nuclear fraction of NF-?B p65 were also significantly lower in MIF KO hearts with I/R.
15	21283592	The increased plasma MIF levels in diabetic patients correlated with plasma glucose, glycosylated hemoglobin and urine albumin levels.