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Gene Information
Gene symbol: MIRN192
Gene name: microRNA 192
HGNC ID: 31562
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | COL1A2 | 1 hits |
| 2 | COL4A1 | 1 hits |
| 3 | CTGF | 1 hits |
| 4 | MIRN21 | 1 hits |
| 5 | PTEN | 1 hits |
| 6 | TGFB1 | 1 hits |
| 7 | ZEB2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 19424061 | Some promote matrix deposition (miR-192 and miR-377) or epithelial-to-mesenchymal transition (miR-200 and miR-205), whereas preliminary findings suggest others might serve protective roles (miR-21). miRNAs recently identified in urinary exosomes could potentially serve as disease biomarkers. |
| 2 | 19543271 | These studies reveal a mechanism of Akt activation through PTEN downregulation by two miRs, which are regulated by upstream miR-192 and TGF-beta. |
| 3 | 20393144 | TGF-beta treatment also modulated the expression of certain miRNAs, including decreased expression of miR-192/215 in tubular cells, mesangial cells, which are also decreased in diabetic kidney. |
| 4 | 20393144 | Ectopic expression of miR-192/215 increased E-cadherin levels via repressed translation of ZEB2 mRNA, in the presence and absence of TGF-beta, as demonstrated by a ZEB2 3'-untranslated region luciferase reporter assay. |
| 5 | 20393144 | In contrast, CTGF increased miR-192/215 levels, causing a decrease in ZEB2, and consequently increased E-cadherin mRNA. |
| 6 | 20056746 | In vitro, treatment of PTCs with TGF-beta1 decreased miR-192 expression. |
| 7 | 20056746 | Overexpression of miR-192 suppressed expression of the E-Box repressors ZEB1 and ZEB2, thereby opposing TGF-beta-mediated downregulation of E-cadherin. |
| 8 | 21389977 | Inhibitors of miR-192 decreased the expression of miR-200b/c, Col1a2, Col4a1, and TGF-?1 in mouse mesangial cells, and in mouse kidney cortex. |