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Gene Information
Gene symbol: MIRN206
Gene name: microRNA 206
HGNC ID: 31584
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HDAC4 | 1 hits |
| 2 | SMAD3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21324893 | We further demonstrate that TGF-? treatment of myogenic cells is associated with increased expression of histone deacetylase 4 (HDAC4), a key inhibitor of muscle differentiation that has been identified as a target for regulation by miR-206 and miR-29. |
| 2 | 21324893 | We confirmed that increased expression of miR-206 and miR-29 resulted in the translational repression of HDAC4 in the presence or absence of TGF-? via interaction with the HDAC4 3'-untranslated region. |
| 3 | 21324893 | Furthermore, we present evidence that the mechanism by which miR-206 and miR-29 can inhibit the TGF-?-mediated up-regulation of HDAC4 is via the inhibition of Smad3 expression, a transducer of TGF-? signaling. |
| 4 | 21324893 | These findings identify a novel mechanism of interaction between TGF-? and miR-206 and -29 in the regulation of myogenic differentiation through HDAC4. |