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Gene Information
Gene symbol: MLL2
Gene name: myeloid/lymphoid or mixed-lineage leukemia 2
HGNC ID: 7133
Synonyms: ALR, MLL4, CAGL114, KMT2D
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | C16orf53 | 1 hits |
| 2 | NCOA6 | 1 hits |
| 3 | PAXIP1 | 1 hits |
| 4 | RARA | 1 hits |
| 5 | TP53BP1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17021013 | Activating signal cointegrator-2 (ASC-2), a coactivator of multiple transcription factors that include retinoic acid receptor (RAR), associates with histone H3-K4 methyltranferases (H3K4MTs) MLL3 and MLL4 in mixed-lineage leukemia. |
| 2 | 17021013 | These results suggest that ASC-2 confers target gene specificity to MLL3 and MLL4 H3K4MT complexes and that recruitment of H3K4MTs to their target genes generally involves interactions between integral components of H3K4MT complexes and transcription factors. |
| 3 | 17500065 | Here we show that while ectopically expressed PTIP is capable of interacting with DNA damage response proteins including 53BP1, endogenous PTIP, and a novel protein PA1 are both components of a Set1-like histone methyltransferase (HMT) complex that also contains ASH2L, RBBP5, WDR5, hDPY-30, NCOA6, SET domain-containing HMTs MLL3 and MLL4, and substoichiometric amount of JmjC domain-containing putative histone demethylase UTX. |