Ignet

Gene Information

Gene symbol: MYC

Gene name: v-myc myelocytomatosis viral oncogene homolog (avian)

HGNC ID: 7553

Synonyms: c-Myc, bHLHe39

Related Genes

#	Gene Symbol	Number of hits
1	AGRP	1 hits
2	CASP3	1 hits
3	CASP8	1 hits
4	CD40LG	1 hits
5	CDC73	1 hits
6	CDK5	1 hits
7	COL1A1	1 hits
8	CYCS	1 hits
9	DDIT3	1 hits
10	E2F1	1 hits
11	EGF	1 hits
12	IGF1	1 hits
13	INS	1 hits
14	ISL1	1 hits
15	KLRG1	1 hits
16	NEUROD1	1 hits
17	NOTCH1	1 hits
18	NOTCH2	1 hits
19	PDX1	1 hits
20	PRKCA	1 hits
21	RSPO1	1 hits
22	SLEV1	1 hits
23	TCF7L2	1 hits
24	TGFB1	1 hits

Related Sentences

#	PMID	Sentence
1	2521209	We studied the growth effects of insulin and IGF-I as measured by stimulation of c-myc, DNA synthesis, and cellular proliferation in the presence and absence of these antibodies.
2	2474397	Peripheral blood mononuclear cells (MNC) of patients with systemic lupus erythematosus (SLE) have increased expression of the c-myc protooncogene.
3	1708099	Cycloheximide treatment resulted in a superinduction of both c-fos and c-myc and prevented any further stimulation by IGF-I.
4	1730782	The exact relationship between EGF-stimulated tyrosine phosphorylation, induction of the cellular proto-oncogenes c-myc and c-fos, and DNA synthesis remains uncertain.
5	1730782	They also suggest that, in MDCK cells, the EGF dependent induction of the c-fos and c-myc genes is not strictly correlated to the extent of EGF receptor autophosphorylation or EGF-stimulated DNA synthesis, and that EGF stimulation of DNA synthesis likely involves additional rate-limiting intermediate steps.
6	8468460	Nuclear transcription of early activation genes (c-fos, c-jun, and c-myc) as determined by nuclear run-off assays, and steady state mRNA levels and/or protein products of intermediate activation genes (IL-2, IL-2R alpha, IL-2R beta, and transferrin receptor) were not affected by TGF-beta 1.
7	11714718	The expression of the basic helix-loop-helix transcription factor c-Myc is induced in pancreatic islets of several different diabetic model animals and is possibly involved in suppression of the insulin gene transcription.
8	11714718	In this study, we found that activity of protein kinase C is increased by high glucose, preceding the induction of c-myc expression and that PKC beta2 specifically regulates c-myc expression in pancreatic beta-cells.
9	11714718	Moreover, c-myc induction by high glucose was suppressed by adenovirus-mediated overexpression of DN PKC beta2 but not by other DN PKC isoforms.
10	11714718	These results suggest that at least some of the reduction of insulin gene transcription found in the diabetic state is mediated by PKC beta2 regulation of c-myc expression.
11	11799123	In gel-shift assays c-Myc bound to the E-box in the insulin gene promoter region.
12	11799123	Furthermore, in betaTC1, MIN6, and HIT-T15 cells and primary rat islets, wild type insulin gene promoter activity was dramatically decreased by c-Myc overexpression, whereas the activity of an E-box mutated insulin promoter was not affected.
13	11799123	In HeLa and HepG2 cells c-Myc exerted a suppressive effect on the insulin promoter activity only in the presence of NeuroD/BETA2 but not PDX-1.
14	11799123	Both c-Myc and NeuroD can bind the E-box element in the insulin promoter, but unlike NeuroD, the c-Myc transactivation domain lacked the ability to activate insulin gene expression.
15	11799123	In conclusion, increased expression of c-Myc in beta-cells suppresses the insulin gene transcription by inhibiting NeuroD-mediated transcriptional activation.
16	12393479	Additional studies showed that HDAC-i treatment inhibited c-Myc expression, which was further shown to be important for CD154 gene activation.
17	16283526	Furthermore, a substantial decrease in the expression of c-myc, an established endogenous transcriptional repressor of gadd45alpha and gadd153 genes, was noted.
18	16887799	Using a Myc-tagged PDX-1 construct, we showed that the translocation of PDX-1 from the nucleus to the cytoplasm during glucotoxic conditions was prevented when CDK5 was inhibited.
19	18302196	In addition to its recently recognized role in diabetes, aberrant TCF7L2 expression has been implicated in cancer through regulation of cell proliferation and apoptosis by c-MYC and cyclin D.
20	18987311	We show here that RNA interference with the expression of parafibromin or Paf1 stimulates cell proliferation and increases levels of the c-myc proto-oncogene product, a DNA-binding protein and established regulator of cell growth.
21	18987311	Knockdown of c-myc blocks the proliferative effect of RNA interference with parafibromin or Paf1 expression.
22	18987311	These experiments provide a previously uncharacterized mechanism for the anti-proliferative action of the parafibromin tumor suppressor protein resulting from PAF1 complex-mediated inhibition of the c-myc proto-oncogene.
23	20442404	Rspo1 activated cWnt signaling in MIN6 beta-cells by increasing nuclear beta-catenin and c-myc, a cWnt target gene.
24	20566667	Wounds were assessed for collagen content, thickness and vascularity of granulation tissue, apoptosis, reepithelialization, and expression of c-myc and beta-catenin.
25	20923823	This was concomitant with increased E2F1 binding to the c-myc promoter.
26	21205112	It regulated c-myc gene expression through the JAK2/STAT system and c-fos and AgRP (agouti-related peptide) gene expression through the ERK1/2 pathway simultaneously and independently.
27	17270172	Our results suggest that quiescence of small cells correlates with up-regulation of Cdk inhibitors p27(Kip1), p16(INK4a) and p21(CIP1), PTEN, Hep27 and Foxo1a and with down-regulation of c-Myc and the receptors for EGF, FGF2 and HGF.
28	17317781	Here we demonstrated that Pdx1 could suppress c-Myc promoter activity, which relied on T cell factor (Tcf) binding elements harbored in c-Myc promoter.
29	17317781	Moreover, adenovirus-mediated Pdx1 interference caused cell proliferation and cytokine-induced apoptosis via the dysregulation of c-Myc transcription.
30	21521872	Bcl-2, Cdk4, and c-myc expression levels were increased in Pax4 islets while MafA, insulin, and GLUT2 transcript levels were suppressed in both animal models.
31	21719578	To this end, we examined the role of cytochrome c in pancreatic ?-cells under homeostatic conditions and in diabetes models, including those induced by streptozotocin (STZ) and c-Myc.
32	21719578	Previous studies have shown that both STZ- and c-Myc-induced ?-cell apoptosis is mediated through caspase-3 activation; however, the precise mechanism in these modes of cell death was not characterized.
33	21719578	We also observed that the extrinsic apoptotic pathway mediated through caspase-8 was not essential in c-Myc-induced ?-cell destruction.
34	21719578	These findings suggest that cytochrome c is not required for STZ-induced ?-cell apoptosis and, together with the caspase-8-mediated extrinsic pathway, plays a redundant role in c-Myc-induced ?-cell apoptosis.
35	21829621	Using HIT-T15 and primary adult islet cells as cell models, we show that ISL1 promoted adult pancreatic islet cell proliferation with increased c-Myc and CyclinD1 transcription, while knockdown of ISL1 increased the proportion of cells in G(1) phase and decreased the proportion of cells in G(2)/M and S phases.
36	21829621	Further investigation shows that ISL1 activated both c-Myc and CyclinD1 transcription through direct binding on their promoters.
37	21494254	With confirmation using RNA and protein analyses, GSI-I blocked nuclear accumulation of cleaved Notch1 and Notch2, and inhibited Notch targets Hey2 and Myc.