Ignet

Gene Information

Gene symbol: MYH14

Gene name: myosin, heavy chain 14, non-muscle

HGNC ID: 23212

Synonyms: FLJ13881, KIAA2034, MHC16, MYH17

Related Genes

#	Gene Symbol	Number of hits
1	ADIPOQ	1 hits
2	CASP3	1 hits
3	CLEC11A	1 hits
4	COL1A1	1 hits
5	HLA-A	1 hits
6	INS	1 hits
7	MAPK1	1 hits
8	MMP2	1 hits
9	MSTN	1 hits
10	MYH7	1 hits
11	MYH9	1 hits
12	MYL6B	1 hits
13	MYLK	1 hits
14	MYO5A	1 hits
15	PIK3CG	1 hits
16	PPA1	1 hits
17	PTH	1 hits
18	SOD1	1 hits
19	TCF7L1	1 hits
20	TPPP3	1 hits
21	TRIM63	1 hits

Related Sentences

#	PMID	Sentence
1	6220614	The effects of insulin, T4, and T3 treatment on cardiac function, myosin ATPase activity, and myosin isozyme distribution were studied in alloxan diabetic rats.
2	6220614	Insulin treatment totally reversed the changes in function, serum thyroid hormones, and myosin ATPase activity.
3	6232127	The fructose-induced increase in Ca++-activated myosin ATPase activity and alteration in myosin isoenzyme distribution occurred in the absence of changes in insulin and thyroid hormone levels or improvement in the general metabolic status of fructose-fed diabetic rats.
4	6238541	Papillary muscle function, actomyosin ATPase, and myosin isoenzyme distribution showed progressive normalization with increasing insulin dose as blood glucose concentration returned to normal.
5	3301474	Insulin stimulated myosin and LDH synthesis by 169 and 184%, respectively.
6	1848561	In this study, we examined the effect of PTH on cytoskeletal actin and myosin, estimated by polyacrylamide gel electrophoresis of Triton X-100 (1%) nonextractable proteins.
7	1848561	After 2-5 minutes, PTH caused a rapid and transient decrease of 50-60% in polymerized actin and myosin associated with the Triton X-100 nonextractable cytoskeleton.
8	1848561	The intracellular calcium chelator Quin-2/AM (10 microM) also decreased cytoskeletal actin and myosin, to the same extent as did PTH (100 nM).
9	1418832	The intracellular Ca-dependent protein kinase C and myosin light chain kinase activities on the phosphorylation of endogenous p47 and p20 proteins studied after 2 min of thrombin addition decreased only 10 to 25% in the presence of 5 to 10 mmol/L Mg.
10	7515882	ML-9, a myosin light chain kinase inhibitor, blocked the effects of insulin and TPA on both MAPK and PP-1 activation.
11	9176186	Previous studies show that diabetes induces marked transformations in cardiac myosin heavy chain (MHC) gene expression that are somehow linked to the cellular action of thyroid hormone 3,5,3'-triiodothyronine (T3).
12	10976915	We conclude that insulin stimulates MBP via its regulatory subunit, MBS partly by inactivating Rho kinase and stimulating NO/cGMP signaling via PI3-kinase as part of a complex signaling network that controls 20-kDa myosin light chain (MLC20) phosphorylation and VSMC contraction.
13	11915909	Using stable isotope tracer methodologies and mass spectrometric detection, we observed: (a) 76-92-year-old physically frail and 62-74-year-old middle-age adults have lower mixed muscle protein synthetic rates than 20-32-year-old men and women; (b) 2 weeks and 3 months of weightlifting exercise increased the synthetic rate of myosin heavy chain (MHC) and mixed muscle proteins to a similar magnitude in frail, middle-age, and young women and men; (c) Serum myostatin-immunoreactive protein levels were elevated in physically frail women and were inversely correlated with lean mass.
14	15131120	Nine proteins, including vimentin, EH-domain-containing protein 2, elongation factor 2, glucose-regulated protein 78, transketolase, and succinyl-CoA transferase were primarily affected by presence or absence of insulin signaling, whereas 21 proteins, including myosin non-muscle form A, annexin 2, annexin A6, and Hsp47 were regulated in relation to adipocyte size.
15	16935841	Nuclear factor-kappaB activation triggered a cascade of signaling, which finally led to the switch in the cardiac myosin heavy-chain (MHC) gene expression from the alpha-MHC isoform to the beta-MHC isoform.
16	17987322	The initial step in this process is activation of caspase-3 to cleave the myofibril into its components (actin, myosin, troponin, and tropomyosin).
17	18319547	This effect of NO-1886 was dependent on extracellular Ca(2+) and intracellular myosin light chain kinase activity.
18	19502378	The cardiac expression of collagen (col1a1) was reduced by approximately 45% and the expression of myosin was switched from the foetal isoform (MHCbeta) to the adult isoform (MHCalpha).
19	20110336	We found that insulin resistance and agonist stimulation increased the expression and activity of MMPs (MMP-2 and MMP-7), the EGFR, contractile proteins such as myosin light chain kinase and MLC II, and their transcriptional activators including P90 ribosomal kinase (P90RSK) and serum response factor, possibly via the activation of extracellular signal-regulated kinase (ERK1/2) in VSMCs.
20	20807613	Genetic variation in MYH9, encoding nonmuscle myosin IIA heavy chain, has been associated recently with increased risk for kidney disease.
21	20836552	Additionally, a shift in cardiac myosin heavy chain (MHC) gene expression from ?- to ?-MHC isoform, decreased levels of superoxide dismutase-1 (SOD-1) and cardiac ?-actin, and elevated cardiac thiobarbituric acid reactive substances (TBARS) and caspase- and p38-NF?B-leading apoptosis signaling activities were demonstrated in diabetic hearts.
22	15198926	Basal myosin light chain (MLC) phosphorylation levels were significantly elevated in response to most stimuli in muscle strips from diabetic animals, although levels of stress were either unchanged or lower. alpha-Toxin-permeabilized strips that allow for control of the intracellular environment while maintaining excitation-contraction coupling showed increased levels of MLC phosphorylation but decreased sensitivity to activator Ca2+ in smooth muscle from diabetic animals.
23	16123338	Mice with heart-specific overexpression of peroxisome proliferator-activated receptor (PPAR)alpha showed a metabolic and cardiomyopathic phenotype similar to the diabetic heart, and we determined tissue-specific glucose metabolism and insulin action in vivo during hyperinsulinemic-euglycemic clamps in awake myosin heavy chain (MHC)-PPARalpha mice (12-14 weeks of age).
24	21620866	In addition, oxidative stress-induced MuRF1 upregulation promoted proteasome dependent degradation of the myosin heavy chain (MHC) in C2C12 myotubes.
25	21914845	Depletion of TCF7L1 inhibits differentiation, because TCF7L1 indirectly induces the adipogenic transcription factor peroxisome proliferator-activated receptor ? in a manner that can be replaced by inhibition of myosin II activity.
26	21842169	In conclusion, diabetic rat brains displayed altered expression and distribution of myosin-Va, and these finding may contribute to the basic understanding about this myosin role in brain function related to diabetes.