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Gene Information
Gene symbol: NCF2
Gene name: neutrophil cytosolic factor 2
HGNC ID: 7661
Synonyms: p67phox, NOXA2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD40 | 1 hits |
| 2 | CYBA | 1 hits |
| 3 | DHFR | 1 hits |
| 4 | EIF2AK2 | 1 hits |
| 5 | EIF2AK3 | 1 hits |
| 6 | GJA1 | 1 hits |
| 7 | GJA5 | 1 hits |
| 8 | GNAS | 1 hits |
| 9 | GORASP1 | 1 hits |
| 10 | NFKBIA | 1 hits |
| 11 | NOX5 | 1 hits |
| 12 | PRKAA1 | 1 hits |
| 13 | PRKCB1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21892921 | RBX normalized these changes with concomitant inhibition of PKC?2 activation and prevention of NADPH oxidase subunit p67phox membrane translocation and p22phox overexpression. |
| 2 | 14514646 | NADPH oxidase activity, which was significantly enhanced in diabetic glomeruli and the source of reactive oxygen species (ROS) generation, was also improved by RBX treatment by preventing the membranous translocation of p47phox and p67phox from cytoplasmic fraction without affecting their protein levels. |
| 3 | 14514646 | Adenoviral-mediated PKC-beta(2) overexpression enhanced ROS generation by modulating the membranous translocation of p47phox and p67phox in cultured mesangial cells. |
| 4 | 20609064 | These findings were accompanied by downregulated Cx43 and Cx40, and upregulated PKCepsilon and NADPH oxidase subunits p22(phox)/p47(phox)/p67(phox) in the thoracic aorta. |
| 5 | 21084672 | Concomitantly, there were significant increases in mRNA and protein expression of AT(1) receptor with increased superoxide levels and expression of NAD(P)H oxidase subunits p22(phox), p47(phox), and p67(phox) in the PVN of rats with diabetes. |
| 6 | 21267711 | With a single injection of streptozotocin 65 mg/kg, ip in rats, early diabetic nephropathy was produced and revealed as an increased microalbuminuria, elevated creatinine and urea in serum, associated with upregulation of mRNA and protein of NADPH oxidase p22phox, p47phox, and p67phox and ET(A), upregulated PKR-like eukaryotic initiation factor 2? kinase (PERK), and downregulated Cx43 in the renal tissue. |
| 7 | 20167927 | The markers of oxidative stress, NAD(P)H oxidase subunit expression (gp91(phox), p47(phox), p67(phox), NOX1 to -4), NAD(P)H oxidase-mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of nuclear factor (NF)-kappaB (p50 and p65) were examined in cultured human umbilical vein endothelial cells and mouse aortas isolated from AMPKalpha2 deficient mice. |
| 8 | 20167927 | Analysis of aortic endothelial cells from AMPKalpha2(-/-) mice and human umbilical vein endothelial cells expressing dominant negative AMPK or AMPKalpha2-specific siRNA revealed that loss of AMPK activity increased NAD(P)H oxidase subunit expression (gp91(phox), p47(phox), p67(phox), NOX1 and -4), NAD(P)H oxidase-mediated superoxide production, 26S proteasome activity, IkappaBalpha degradation, and nuclear translocation of NF-kappaB (p50 and p65), whereas AMPK activation by AICAR or overexpression of constitutively active AMPK had the opposite effect. |
| 9 | 18061195 | In STZ rats, atorvastatin feeding (20 mg/kg/d, 7 weeks), normalized vascular dysfunction as analyzed by isometric tension studies, levels of circulating endothelial progenitor cells (FACS-analysis), superoxide formation (assessed by lucigenin-enhanced chemiluminescence and dihydroethidium staining), vascular levels of the phosphorylated vasodilator-stimulated phosphoprotein (P-VASP), tyrosine nitration of the prostacyclin synthase, expression of GTPCH-I, dihydrofolate reductase and eNOS, translocation of regulatory NADPH oxidase subunits rac1, p47phox and p67phox (assessed by Western blot) and vascular tetrahydrobiopterin levels as measured by HPLC. |
| 10 | 20175116 | GSPs treatment remarkably disrupted the phosphorylation and membrane translocation of Rac1, p47phox, and p67phox subunits. |