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Gene Information
Gene symbol: NCOR1
Gene name: nuclear receptor corepressor 1
HGNC ID: 7672
Synonyms: N-CoR, hCIT529I10, TRAC1, hN-CoR, KIAA1047, MGC104216
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HDAC3 | 1 hits |
| 2 | IFNGR2 | 1 hits |
| 3 | INS | 1 hits |
| 4 | NCOR2 | 1 hits |
| 5 | PPARG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 11509652 | A cognate DAD is present in the related corepressor N-CoR, which can also activate HDAC3. |
| 2 | 12482846 | An ERalpha mutation (537X) that increases N-CoR binding in the presence of all SERMs blocks AF-1 activity. |
| 3 | 12482846 | An ERalpha mutation (L379R) that decreases N-CoR binding increases AF-1 activity in the presence of ICI and raloxifene and reverses the effect of the 537X mutation. |
| 4 | 19037247 | Lack of Ncor1 is incompatible with life, and hence it is unknown whether Ncor1, and particularly its regulation of Hdac3, is critical for adult mammalian physiology. |
| 5 | 19165156 | Recently, we and others have shown that PPARgamma recruits the nuclear corepressors NCoR and silencing mediator for retinoid and thyroid hormone receptors (SMRT) to modulate adipogenesis. |
| 6 | 20427468 | Thus, the NCoR interaction with HDAC3 modulates expression of both positively- and negatively-regulated genes by TH in vivo. |
| 7 | 22078880 | The dominant function of adipocyte NCoR is to transrepress PPAR? and promote PPAR? ser-273 phosphorylation, such that NCoR deletion leads to adipogenesis, reduced inflammation, and enhanced systemic insulin sensitivity, phenocopying the TZD-treated state. |