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Gene Information
Gene symbol: NEU1
Gene name: sialidase 1 (lysosomal sialidase)
HGNC ID: 7758
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ALPP | 1 hits |
| 2 | IGHA1 | 1 hits |
| 3 | INS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 3407769 | Adipocytes treated with neuraminidase show markedly reduced responsiveness to insulin without any alteration in insulin binding. |
| 2 | 3407769 | At a concentration of neuraminidase that decreases insulin action by 50%, 23% of total cellular sialic acid content was released. |
| 3 | 2666202 | The enzyme action on glucose transport was not due to a nonspecific membrane perturbation because neuraminidase caused only a nonsignificant decrease in the uptake of the amino acid analog alpha-(methylamino)isobutyric acid and had no effect on basal or insulin-stimulated protein synthesis. |
| 4 | 2666202 | Insulin binding was slightly increased in neuraminidase-treated cells, yet the shapes of the dose-response curves for insulin stimulation of glucose transport were similar (EC50 = 0.087 +/- 0.010 and 0.082 +/- 0.008 nM for control and treated cells, respectively). |
| 5 | 1727740 | Furthermore, liver binding data were not due to cross-reaction of 125I-labeled insulin to the insulinlike growth factor I receptor, and treatment of liver membranes with neuraminidase did not alter the inhibitory effect of the IgGa fraction from patient I-2 on 125I-labeled insulin binding to liver. |
| 6 | 1568315 | The more-cathodic intestinal ALP, which comigrated with ALP from colonic mucosa, was completely inhibited by levamisole and converted by neuraminidase to a species with a more basic pI than that of neuraminidase-digested tissue-nonspecific form. |
| 7 | 8046546 | Intestinal variant ALP is most likely composed of intestinal ALP attached to a cellular membrane-binding domain, or may be an artifact produced by neuraminidase incubation. |
| 8 | 18045697 | Also neuraminidase treatment significantly reduced the titre of free (non-immune complexed) anti-T in serum, while selective removal of anti-T by affinity absorption resulted in considerable decrease in the amount of IgA1 that got converted to immune complexes following enzymatic desialylation of serum. |