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Gene Information
Gene symbol: NKX2-1
Gene name: NK2 homeobox 1
HGNC ID: 11825
Synonyms: TTF-1, TTF1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AGRP | 1 hits |
| 2 | POMC | 1 hits |
| 3 | SSBP1 | 1 hits |
| 4 | TG | 1 hits |
| 5 | TSHR | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 7828540 | FRTL-5, but not FRT or BRL cell nuclear extracts, form a specific protein-DNA complex with this region in gel mobility shift analyses; its formation is prevented by TTF-1-binding elements from the thyroglobulin promoter. |
| 2 | 7709602 | TTF-1 is implicated as a critical autoregulatory component in both positive and negative regulation of the TSHR and appears to be the link between TSH, the TSHR, TSHR-mediated signals, TG and TPO biosynthesis, and thyroid hormone formation. |
| 3 | 7709602 | Differentially regulated expression of the TSHR and TG by cAMP and insulin depend on differences in the specificity of the TTF-1 site, that is, the lack of Pax-8 interactions with the TSHR, and the IRE sites. |
| 4 | 7565801 | An element, -186 to -176 base pairs (bp), in the minimal TSH receptor (TSHR) promoter binds thyroid transcription factor-1 (TTF-1) and is important for both constitutive expression and TSH/cAMP-induced negative autoregulation of the TSHR in thyroid cells. |
| 5 | 7565801 | Transfection experiments indicate that full, constitutive TSHR gene expression in FRTL-5 thyroid cells requires the binding of both SSBPs and TTF-1, since mutation of either element halves thyroid-specific promoter activity, whereas mutation of both decreases promoter activity to values near those of a control vector. |
| 6 | 7565801 | In sum, full, constitutive expression of the TSHR in thyroid cells requires TTF-1 and the SSBPs to bind separate, contiguous elements on the TSHR promoter. |
| 7 | 7565801 | The role of the SSBP and TTF-1 sites in constitutive TSHR expression and in TSH/cAMP-induced negative regulation of the TSHR is, therefore, additive and independent. |
| 8 | 8923467 | Mutation analyses indicate that it is functionally distinct from the TTF-1 element and is important for the constitutive expression and TSH/cAMP-induced negative autoregulation of the TSHR in thyroid cells but only constitutive expression in nonthyroid cells. |
| 9 | 8923467 | SSBP-1 RNA is present ubiquitously; however, its levels are higher in FRTL-5 cells and are increased by overexpression of TTF-1 in cells treated with TSH. |
| 10 | 21282365 | TTF-1 activity in AgRP and pro-opiomelanocortin (POMC) transcription was examined using gel-shift and promoter assays and an in vivo model of TTF-1 synthesis inhibition by intracerebroventricular injection of an antisense (AS) oligodeoxynucleotide (ODN). |
| 11 | 21282365 | TTF-1 stimulated AgRP but inhibited POMC transcription by binding to the promoters of these genes. |
| 12 | 21282365 | TTF-1 transcriptionally regulates synthesis of AgRP and ?-MSH in the ARC and affects feeding behavior via the melanocortin pathway. |