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Gene Information

Gene symbol: NPR1

Gene name: natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

HGNC ID: 7943

Synonyms: GUCY2A, ANPa

Related Genes

#	Gene Symbol	Number of hits
1	MAPK1	1 hits
2	MAPK14	1 hits
3	NOS3	1 hits
4	NPPA	1 hits
5	SGK1	1 hits

Related Sentences

#	PMID	Sentence
1	16436087	The ANP and NPR-C mRNA expressions were only altered after 3 weeks, whereas BNP, CNP and NPR-A mRNA expressions were not altered in STZ-treated-mouse hearts at any of the time points.
2	17054659	Maximal activation of NPR-A guanylyl cyclase (GC) requires ANP binding and ATP interaction with a putative cytoplasmic site.
3	15126246	In addition, using affinity cross-linking studies we have observed that water deprivation increases the expression of the 67-kDa NPR-C-like protein, and HS-142, which binds to NPR-A and the 77-kDa NPR-C-like but not the 67-kDa protein, reduced ligand internalization without affecting cAMP inhibition by ANP(1-28).
4	15007040	Neither Sgk1 nor the kinase-dead mutant had any effect on endothelial nitric oxide synthase (eNOS) promoter activity, and the Sgk1 mutant and 8-bromo-cyclic guanosine monophosphate were, to some degree, additive in reducing osmotically stimulated NPR-A promoter activity.
5	15007040	Collectively, these data imply that Sgk1 operates over an eNOS-independent, p38 MAPK-dependent pathway in mediating osmotic induction of the NPR-A gene promoter.
6	19436108	In vivo, water restriction of rats or mice led to increased urine osmolality, increased Sgk1 expression, increased expression of the type A natriuretic peptide receptor (NPR-A), and dehydration natriuresis.
7	19436108	In cultured rat renal medullary cells, siRNA-mediated Sgk1 knockdown blocked the osmotic induction of natriuretic peptide receptor 1 (Npr1) gene expression.