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Gene Information

Gene symbol: NR1H2

Gene name: nuclear receptor subfamily 1, group H, member 2

HGNC ID: 7965

Synonyms: NER, NER-I, RIP15, LXR-b

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	NR1H3	1 hits
3	UCP1	1 hits

Related Sentences

#	PMID	Sentence
1	19690071	Using tolerance tests, we found that, on an HFD, LXRbeta(-/-) mice enhanced their endogenous glucose production and became highly insulin resistant, whereas LXRalpha(-/-) and LXRalphabeta(-/-) mice remained glucose tolerant and insulin sensitive.
2	19690071	Gene expression profiling confirmed that LXRbeta is the regulator of lipogenic genes in visceral white adipose tissue (WAT) and muscle tissue and, surprisingly, that Ucp1 and Dio2 are not responsible for the protection against diet-induced obesity observed in LXRbeta(-/-) and LXRalphabeta(-/-) mice.
3	19690071	LXRalpha is required for the control of cholesterol metabolism in the liver, while LXRbeta appears to be a major regulator of glucose homeostasis and energy utilization and of fat storage in muscle and WAT.
4	21042792	NR1H2 rs2248949 was nominally associated with OGTT-derived first-phase insulin secretion and proinsulin conversion to insulin and significantly associated with the AUC of insulin levels during the IVGTT (p?=?0.007) after adjustment for age, gender, BMI and insulin sensitivity in the dominant model, with the minor allele conferring reduced pancreatic ?-cell function to the carriers.
5	21042792	In subjects of European ancestry at increased risk for type 2 diabetes, common variation within the NR1H2 gene impaired insulin secretion, which may facilitate the development of type 2 diabetes.