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Gene Information
Gene symbol: NR1H3
Gene name: nuclear receptor subfamily 1, group H, member 3
HGNC ID: 7966
Synonyms: LXR-a, RLD-1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ABCA1 | 1 hits |
| 2 | ABCG1 | 1 hits |
| 3 | APLP2 | 1 hits |
| 4 | APOC3 | 1 hits |
| 5 | FASN | 1 hits |
| 6 | NR1H2 | 1 hits |
| 7 | NR3C1 | 1 hits |
| 8 | OGT | 1 hits |
| 9 | PPARA | 1 hits |
| 10 | PPARG | 1 hits |
| 11 | PTPN1 | 1 hits |
| 12 | SOCS3 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12942148 | PPARgamma has also been demonstrated to act through the liver X receptor alpha to increase the activity of reverse cholesterol transport in these cells. |
| 2 | 17522048 | Liver X receptor (LXR) activates fatty acid synthase (FAS) gene expression through binding to a DR-4 element in the promoter. |
| 3 | 18755798 | Working as an inhibitor of 11beta-reductase activity, 7KC decreased the regeneration of active glucocorticoid and limited the process of differentiation of 3T3-L1 preadipocytes. 7KC and 7beta-HC did not activate liver X receptor in a transactivation assay, nor did they display intrinsic activation of the glucocorticoid receptor. |
| 4 | 18796617 | When using a pharmacological approach, liver X receptor agonists overcome IL-6-induced insulin resistance by producing downregulation of socs3 and ptp1b gene expression. |
| 5 | 18849545 | Conclusions: We propose that ritonavir induces ABCA1 expression in THP-1 macrophages through LXRalpha. |
| 6 | 19690071 | Using tolerance tests, we found that, on an HFD, LXRbeta(-/-) mice enhanced their endogenous glucose production and became highly insulin resistant, whereas LXRalpha(-/-) and LXRalphabeta(-/-) mice remained glucose tolerant and insulin sensitive. |
| 7 | 19690071 | LXRalpha is required for the control of cholesterol metabolism in the liver, while LXRbeta appears to be a major regulator of glucose homeostasis and energy utilization and of fat storage in muscle and WAT. |
| 8 | 20811644 | We show it activates the ligand-binding domain of both PPARalpha and PPARgamma, while inhibiting LXRalpha in GAL4-fusion reporters. |
| 9 | 19933273 | In the present study, we show for the first time that LXRalpha and LXRbeta are targets for glucose-hexosamine-derived O-GlcNAc modification in human Huh7 cells. |
| 10 | 18490524 | Macrophage expression of ABCG1 in both patients and control subjects was induced by treatment with the liver X receptor agonist TO-901317. |
| 11 | 21183731 | ApoCIII induction by glucose is blunted by treatment with agonists of farnesoid X receptor and peroxisome proliferator-activated receptor-? but not liver X receptor, ie, nuclear receptors controlling triglyceride metabolism. |
| 12 | 21568932 | Agonists of liver X receptor (LXR) reduce amyloid in brain plaques and improve cognitive performance in mouse models of Alzheimer's disease. |