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Gene Information
Gene symbol: NR1I2
Gene name: nuclear receptor subfamily 1, group I, member 2
HGNC ID: 7968
Synonyms: ONR1, PXR, BXR, SXR, PAR2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BCL2 | 1 hits |
| 2 | CYP2B6 | 1 hits |
| 3 | CYP3A4 | 1 hits |
| 4 | DKK1 | 1 hits |
| 5 | JUN | 1 hits |
| 6 | MAPK8 | 1 hits |
| 7 | NCOA1 | 1 hits |
| 8 | NFKB1 | 1 hits |
| 9 | NR0B2 | 1 hits |
| 10 | PARP1 | 1 hits |
| 11 | PTGS2 | 1 hits |
| 12 | TBXAS1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21920351 | SHP suppresses the functions of several nuclear receptors involved in the regulation of hepatic metabolism, including pregnane X receptor (PXR), which is referred to as a "master regulator" of drug/xenobiotic metabolism. |
| 2 | 21920351 | We show that metformin dramatically suppresses PXR-mediated expression of CYP3A4 in hepatocytes. |
| 3 | 21920351 | We show that metformin disrupts PXR's interaction with steroid receptor coactivator-1 (SRC1) in a two-hybrid assay independently of the PXR ligand binding pocket. |
| 4 | 19675559 | Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes. |
| 5 | 19861503 | We hypothesized that glucose-induced up-regulation of PRR leads to increased production of the proinflammatory factors IL-1beta and cyclooxygenase-2 (COX-2). |
| 6 | 19861503 | The results showed that D-glucose treatment up-regulates prorenin, renin, angiotensin II, PRR, IL-1beta, and COX-2 mRNA and protein expression and increases phosphorylation of ERK1/2, c-Jun N-terminal kinase, c-Jun, and nuclear factor-kappaB (NF-kappaB) p65 (serine 276,468 and 536), respectively. |
| 7 | 19861503 | We conclude that glucose induces the up-regulation of PRR and its ligands prorenin and renin, leading to increased IL-1beta and COX-2 production via the angiotensin II-dependent pathway. |
| 8 | 19900402 | Further, the combination also reduced the overactivation of PARP as evident from increased NAD levels and decreased PAR immunopositivity in sciatic nerve microsections. |
| 9 | 20444941 | We hypothesized that high glucose up-regulates PRR through protein kinase C (PKC)-Raf-ERK and PKC-c-Jun N-terminal kinase (JNK)-c-Jun signaling pathways. |
| 10 | 20444941 | Rat mesangial cells exposed to 30 mm d-glucose demonstrated significant increase in PRR mRNA and protein expression, intracellular phosphorylation of Raf-1 (Y340/341), ERK, JNK, nuclear factor-kappaB (NF-kappaB) p65 (S536) and c-Jun (S63). |
| 11 | 20444941 | By chromatin immunoprecipitation assay and EMSA, high glucose induced more functional NF-kappaB and activator protein (AP)-1 dimers bound to corresponding cis-regulatory elements in the predicted PRR promoter to up-regulate PRR transcription. |
| 12 | 20444941 | NF-kappaB and AP-1 are involved in high-glucose-induced PRR up-regulation in rat mesangial cells. |
| 13 | 21496888 | The extent of oxidative stress and apoptosis, expression of poly(ADP-ribose) (PAR), NF-?B, phosphorylated inhibitor of NF-?B (I?B)-?, Bcl-2, and Bax in the bladder were also investigated. |
| 14 | 17591676 | Treatment of rats with DHEA influences expression of cytochrome P450 (P450) genes, including peroxisome proliferator-activated receptor alpha (PPAR alpha)- and pregnane X receptor (PXR)-mediated induction of CYP4As and CYP3A23, and suppression of CYP2C11. |
| 15 | 17591676 | Because CYP2B6 induction by DHEA in human hepatocytes might involve either PXR or constitutive androstane receptor (CAR) activation, we performed experiments in primary hepatocytes from CAR knockout mice and observed that CAR was required for maximal induction of Cyp2b10 by DHEA. |