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Gene Information
Gene symbol: NR3C1
Gene name: nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
HGNC ID: 7978
Synonyms: GR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AGRP | 1 hits |
| 3 | AR | 1 hits |
| 4 | FKBP5 | 1 hits |
| 5 | GSK3B | 1 hits |
| 6 | HSD11B1 | 1 hits |
| 7 | HSD11B2 | 1 hits |
| 8 | IL6 | 1 hits |
| 9 | INS | 1 hits |
| 10 | NR1H3 | 1 hits |
| 11 | PCK1 | 1 hits |
| 12 | PCK2 | 1 hits |
| 13 | PDX1 | 1 hits |
| 14 | SLC37A4 | 1 hits |
| 15 | STAT5A | 1 hits |
| 16 | WARS | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 9395482 | Treatment of obese diabetic db/db transgenic mice with the glucocorticoid receptor blocker RU 486 decreased plasma glucose by 50% and reduced PEPCK, GLUT2, glucose-6-phosphatase, tyrosine aminotransferase, CRP, and hGx reporter gene expression to levels similar to those of non-obese normoglycemic transgenic mice. |
| 2 | 16100117 | Transient transfections in HepG2 human hepatoma cells showed that glucocorticoid receptor interacts with several non-steroid nuclear receptors, yielding a synergistic response of the PEPCK-C gene promoter to glucocorticoids. |
| 3 | 18225986 | Similarly, after 16-day treatment with CBX, exogenous insulin evoked a significantly greater reduction in glucose concentrations (1.4- to 1.8-fold). 11beta-HSD1 gene expression was significantly down-regulated in liver, whereas glucocorticoid receptor gene expression was increased in both liver and adipose tissue following CBX treatment. |
| 4 | 18755798 | Working as an inhibitor of 11beta-reductase activity, 7KC decreased the regeneration of active glucocorticoid and limited the process of differentiation of 3T3-L1 preadipocytes. 7KC and 7beta-HC did not activate liver X receptor in a transactivation assay, nor did they display intrinsic activation of the glucocorticoid receptor. |
| 5 | 18838540 | Here, we discovered a new target for GSK-3beta phosphorylation: the human glucocorticoid receptor (GR). |
| 6 | 20022934 | JNK1-deficient mice feed more upon central administration of glucocorticoids, and glucocorticoid receptor nuclear immunoreactivity is enhanced in the AgRP neurons. |
| 7 | 21123945 | In perfused liver and primary mouse hepatocytes, LXR? was required for glucocorticoid-induced recruitment of the glucocorticoid receptor to the PEPCK promoter. |
| 8 | 19436110 | The glucocorticoid receptor is a negative regulator of IL-6 transcription; in the absence of Foxa1/2, the glucocorticoid receptor failed to bind to the IL-6 promoter, causing enhanced IL-6 expression. |
| 9 | 21163329 | Abnormal hepatic gluconeogenesis contributes significantly to both fasting and non-fasting hyperglycemia of patients with type 2 diabetes. 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) regulates the key hepatic gluconeogenic enzymes including phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase) through the amplification of glucocorticoid receptor (GR) - mediated tissue glucocorticoid action, and is crucially dependent on hexose-6-phosphate dehydrogenase (H6PDH) - generating NADPH system. |
| 10 | 20478996 | During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer-binding protein beta (CEBPbeta), p300, mediator subunit 1, and histone H3 acetylation near genes involved in cell proliferation, development, and differentiation, including the gene encoding the master regulator of adipocyte differentiation, peroxisome proliferator-activated receptor gamma2 (PPARgamma2). |
| 11 | 16612121 | To investigate whether this is also the case in human pancreatic development, we studied the expression of the glucocorticoid receptor and that of the transcription factor Pdx-1 on pancreatic specimens from very early to late stages of development of the human embryo. |
| 12 | 21565552 | Its cellular properties suggest numerous possible functions for FKBP51 in physiology, and the best clue to its potential importance may be the following: FKBP51 is a glucocorticoid-induced negative regulator of the glucocorticoid receptor. |
| 13 | 21565552 | In contrast to glucocorticoid receptor, FKBP51 is a positive regulator of the androgen receptor, suggesting that it functions as a reciprocal modulator of glucocorticoid-mediated and androgen-mediated physiology. |
| 14 | 21806804 | We measured maternal serum levels of corticosterone, and the placental basal and labyrinth zone expression of glucocorticoid receptor (NR3C1), 11-hydroxysteroid dehydrogenase B 1 (HSD11B-1) predominantly activates cortisone to cortisol and 11-dehydrocorticosterone (11-DHC) to corticosterone, although can sometimes drive the opposing (inactivating reaction), and HSD11B-2 (only inactivates and converts corticosterone to 11-DHC in rodents) in control and MUN rats at embryonic day 20 (E20). |
| 15 | 21806804 | Notably, the placental labyrinth zone, the site of feto-maternal exchange, showed decreased expression of HSD11B1-2 in both horns, and increased HSD11B-1 in proximal-horn placentas, but no change in NR3C1. |
| 16 | 18347089 | Second, we present an example of how STAT5 can achieve cell specificity in hepatocytes through a physical and functional interaction with the glucocorticoid receptor. |