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Gene Information
Gene symbol: NR4A1
Gene name: nuclear receptor subfamily 4, group A, member 1
HGNC ID: 7980
Synonyms: TR3, N10, NAK-1, NGFIB, NUR77
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | GCG | 1 hits |
| 2 | INS | 1 hits |
| 3 | SERPINE1 | 1 hits |
| 4 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12941761 | In contrast, HMR 1964 produced a marginal activation of the Shc/ERK kinase cascade and was equipotent to insulin in stimulating DNA synthesis in myoblasts. |
| 2 | 17785466 | After observing that expression of two NR4A orphan nuclear receptors, NR4A3 and NR4A1, was altered by insulin in cDNA microarray analyses of human skeletal muscle, we studied whether these receptors could modulate insulin sensitivity. |
| 3 | 17785466 | We found that both NR4A3 and NR4A1 were induced by insulin and by thiazolidinedione drugs (pioglitazone and troglitazone) in 3T3-L1 adipocytes. |
| 4 | 17785466 | Furthermore, gene expression of NR4A3 and NR4A1 was reduced in skeletal muscles and adipose tissues from multiple rodent models of insulin resistance. |
| 5 | 17785466 | Thus, NR4A3 and NR4A1 are attractive novel therapeutic targets for potential amelioration of insulin resistance, and treatment and prevention of type 2 diabetes and the metabolic syndrome. |
| 6 | 18180317 | Taken together, these observations suggest that GLP-1 inhibits TNF-alpha-mediated PAI-1 induction in vascular endothelial cells, and this effect may involve Akt-mediated signalling events and the modulation of Nur77 expression and NP binding to the PAI-1 NBRE. |
| 7 | 19819977 | Expression of the orphan nuclear receptor Nur77, which is induced by beta-adrenergic signaling and is associated with insulin sensitivity, was lower in LCR (P < 0.05). |
| 8 | 19741162 | Loss of Nur77 expression in skeletal muscle impaired insulin signaling and markedly reduced GLUT4 protein expression. |
| 9 | 20525362 | Therefore, we investigated in a cohort of white European subjects at increased risk for type 2 diabetes whether genetic variation within the NR4A1 gene locus contributes to prediabetic phenotypes, such as insulin resistance, ectopic fat distribution, or beta-cell dysfunction. |