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Gene Information
Gene symbol: NR4A3
Gene name: nuclear receptor subfamily 4, group A, member 3
HGNC ID: 7982
Synonyms: CSMF, CHN, NOR1, MINOR
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17785466 | We found that both NR4A3 and NR4A1 were induced by insulin and by thiazolidinedione drugs (pioglitazone and troglitazone) in 3T3-L1 adipocytes. |
| 2 | 17785466 | Furthermore, gene expression of NR4A3 and NR4A1 was reduced in skeletal muscles and adipose tissues from multiple rodent models of insulin resistance. |
| 3 | 17785466 | To determine whether NR4A3 could modulate insulin sensitivity, 3T3-L1 adipocytes were stably transduced with NR4A3 or LacZ (control) lentiviral vectors. |
| 4 | 17785466 | Compared with LacZ expressing cells, hyperexpression of NR4A3 increased the ability of insulin to augment glucose transport activity, and the mechanism involved increased recruitment of GLUT4 glucose transporters to the plasma membrane. |
| 5 | 17785466 | NR4A3 hyperexpression also led to an increase in insulin-mediated tyrosine phosphorylation of insulin receptor substrate-1 as well as Akt phosphorylation. |
| 6 | 17785466 | Suppression of NR4A3 using lentiviral short hairpin RNA constructs reduced the ability of insulin to stimulate glucose transport and phosphorylate Insulin receptor substrate-1 and Akt. |