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Gene Information
Gene symbol: NR5A2
Gene name: nuclear receptor subfamily 5, group A, member 2
HGNC ID: 7984
Synonyms: FTZ-F1beta, hB1F, LRH-1, FTZ-F1, hB1F-2, B1F2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | FASN | 1 hits |
| 3 | INS | 1 hits |
| 4 | NR0B2 | 1 hits |
| 5 | PPARG | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 12829629 | LRH-1 augmented PPAR-gamma-induced transactivation of adiponectin promoter, and point mutation of the LRH-RE significantly decreased the basal and thiazolidinedione-induced activities of adiponectin promoter. |
| 2 | 12829629 | Our results indicate that PPAR-gamma and LRH-1 play significant roles in the transcriptional activation of adiponectin gene via the PPRE and the LRH-RE in its promoter. |
| 3 | 17522048 | We also demonstrate that LRH-1 stimulation of the FAS LXR response is blocked by the addition of small heterodimer partner (SHP) and that FAS mRNA is overexpressed in SHP knock-out animals, providing evidence that FAS is an in vivo target of SHP repression. |
| 4 | 17522048 | Taken together, these findings identify the first direct lipogenic gene target of LRH-1/SHP repression and provide a mechanistic explanation for bile acid repression of FAS and lipogenesis recently reported by others. |
| 5 | 20647474 | The associations of the ABO blood group gene and NR5A2 gene variants with PC discovered by recent genome-wide association studies may link insulin resistance, inflammation, and thrombosis to pancreatic carcinogenesis. |