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Gene Information
Gene symbol: NTRK1
Gene name: neurotrophic tyrosine kinase, receptor, type 1
HGNC ID: 8031
Synonyms: TRK, TRKA, MTC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | BDNF | 1 hits |
| 2 | CTGF | 1 hits |
| 3 | NTRK3 | 1 hits |
| 4 | NTSR1 | 1 hits |
| 5 | PSIP1 | 1 hits |
| 6 | SHC1 | 1 hits |
| 7 | TAC1 | 1 hits |
| 8 | TGFB1 | 1 hits |
| 9 | VEGFA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21872660 | Similarly, Trk A-positive peptidergic IENF, which also express substance P and calcitonin gene related peptide in db/db mice, were observed to be elevated from 1.5 to 2 fold over controls. |
| 2 | 7499194 | Phosphopeptide assays developed to compare PTB domain specificities show that the Shc PTB domain binds with highest affinity to psi XN beta 1 beta 2 pY motifs derived from middle T (mT), TrkA, ErbB4, or epidermal growth factor receptors (psi = hydrophobic, beta = beta-turn forming); the IRS-1 PTB domain does not bind with this motif. |
| 3 | 8584261 | In addition, diabetes induced a reduction in the expression levels of the neurotrophin receptors: trkB mRNA decreased by 50% after 6 weeks of diabetes, but returned to control levels after 12 weeks; meanwhile the trkC and p75LNGFR transcripts were reduced by 20% of control at both times studied. trkA expression was below detection limits. |
| 4 | 15555528 | EPA depresses vascular endothelial growth factor (VEGF)-specific tyrosine kinase receptor activation and expression. |
| 5 | 19214781 | CTGF is also able to interact with receptors on cells, including integrins, tyrosine receptor kinase A (TrkA), low density lipoprotein receptor-related protein (LRP) and heparan sulphate proteoglycans. |
| 6 | 19214781 | It can promote TGF-beta signalling by binding directly to the growth factor, promoting its interaction with the TGF-beta receptor; by triggering intracellular signalling on binding the TrkA receptor, which leads to the transcriptional repression of Smad7, an inhibitor of the TGF-beta signalling pathway; and by binding to BMP-7 whose own signalling pathway opposing TGF-beta is inhibited, leading to enhanced TGF-beta signalling. |
| 7 | 21136036 | It also impairs TrkA receptor phosphorylation and activates the p75(NTR) apoptotic pathway in RGCs, leading to neuronal cell death. |