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Gene Information
Gene symbol: NTRK3
Gene name: neurotrophic tyrosine kinase, receptor, type 3
HGNC ID: 8033
Synonyms: TRKC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CCND1 | 1 hits |
| 3 | MAPK1 | 1 hits |
| 4 | NTRK1 | 1 hits |
| 5 | NTRK2 | 1 hits |
| 6 | PIK3CA | 1 hits |
| 7 | SRC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8584261 | In addition, diabetes induced a reduction in the expression levels of the neurotrophin receptors: trkB mRNA decreased by 50% after 6 weeks of diabetes, but returned to control levels after 12 weeks; meanwhile the trkC and p75LNGFR transcripts were reduced by 20% of control at both times studied. trkA expression was below detection limits. |
| 2 | 17991742 | TrkC expression leads to the constitutive activation of two major effector pathways, namely the Ras-MAP kinase (MAPK) mitogenic pathway and the phosphatidylinositol 3-kinase (PI3K)-AKT pathway mediating cell survival. |
| 3 | 17991742 | We show that endogenous TrkC associated with c-Src in human and mouse cancer cells which express TrkC. |
| 4 | 17991742 | Suppression of c-Src by RNA interference in highly metastatic 4T1 mammary cancer cells, which express endogenous TrkC, resulted in markedly decreased expression of cyclin D1 and suppression of activation of Ras-Erk1/2 and PI3K-Akt. |
| 5 | 17991742 | Therefore these data indicate that TrkC induces the PI3K-Akt cascade through the activation of c-Src. |