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Gene Information
Gene symbol: NUDT6
Gene name: nudix (nucleoside diphosphate linked moiety X)-type motif 6
HGNC ID: 8053
Synonyms: gfg-1, gfg, FGF2AS, FGF-AS
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ANXA5 | 1 hits |
| 2 | DBI | 1 hits |
| 3 | FGF4 | 1 hits |
| 4 | FGF7 | 1 hits |
| 5 | FGFR1 | 1 hits |
| 6 | FOXA2 | 1 hits |
| 7 | INS | 1 hits |
| 8 | MAPK1 | 1 hits |
| 9 | NEUROD1 | 1 hits |
| 10 | ONECUT1 | 1 hits |
| 11 | PAX6 | 1 hits |
| 12 | PIK3CA | 1 hits |
| 13 | PLCG1 | 1 hits |
| 14 | POU5F1 | 1 hits |
| 15 | PRKCA | 1 hits |
| 16 | PSMD9 | 1 hits |
| 17 | PTHLH | 1 hits |
| 18 | TNF | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 8013761 | Furthermore, although both FGF-2 and HGF/SF increased the total insulin content of the cultures, only HGF/SF increased the insulin content per DNA. |
| 2 | 7896883 | In addition, the recombinant extracellular domain of FGFR-1 continues to bind to corneal endothelial cell matrix after endogenous FGF-2 has been removed with 2 M NaCl. |
| 3 | 10748122 | FGF-1 and FGF-2 competed efficiently with (125)I-FGF-2 for binding to FGFR-1 and FGFR-1L, whereas FGF-4 was less efficient. |
| 4 | 10748122 | FGF-1, FGF-2, and FGF-4 enhanced mitogen-activated protein kinase (MAPK) activity, increased steady-state c-fos mRNA levels, and stimulated proliferation through either receptor, whereas KGF was without effect. |
| 5 | 10748122 | These findings indicate that FGFR-1L binds FGF-1 and FGF-2 with high affinity and is capable of mitogenic signaling, but may activate MAPK to occur via non-classical signaling intermediates. |
| 6 | 11181569 | Consistent with the in vivo observations, FGF2 inhibited bone growth in culture and induced downregulation of IHH and PTHrP receptor gene expression. |
| 7 | 16079311 | We conclude that physiological glucose concentrations are suitable for the culturing of EBs, that the addition of FGF2 enhances the temporal expression of genes including POU5F1, nestin, FOXA2, ONECUT1, NEUROD1, PAX6, and insulin, and that EBs can be cultured in vitro for long periods, allowing for further examination of developmental processes. |
| 8 | 17109637 | Taken together these data strongly suggest that FGF1 and FGF2 induce proliferation of pancreatic epithelial cells during the early post-natal period whereas FGF7 is not strictly specific for pancreatic cell proliferation. |
| 9 | 20011604 | We show that FGF-2 activates PLCgamma1 in HUVECs measured by analysis of total inositol phosphates production upon metabolic labelling of cells and intracellular calcium increase. |
| 10 | 20011604 | We further demonstrate that FGF-2 activates PI3K, assessed by analysing accumulation of its lipid product phosphatidylinositol-3,4,5-P(3) using TLC and confocal microscopy analysis. |
| 11 | 20011604 | PI3K activity is required for FGF-2-induced PLCgamma1 activation and the PI3K/PLCgamma1 pathway is involved in FGF-2-dependent cell migration, determined using Transwell assay, and in FGF-2-induced capillary tube formation (tubulogenesis assays in vitro). |
| 12 | 20011604 | This occurs through protein kinase C (PKC)alpha activation since dowregulation of PKCalpha expression using specific siRNA or blockade of its activity using chemical inhibition affects the FGF-2-dependent Ser473 Akt phosphorylation. |
| 13 | 18446810 | Porcine aortic endothelial cells were cultured in 5 and 30 mM glucose and stimulated with TNFalpha, together with FGF-2 or a neutralizing FGF-2 antibody. |
| 14 | 18446810 | TNFalpha-induced endothelial cell death increased for cells in high glucose, and cell death was enhanced with increasing FGF-2 exposure and negated by a neutralizing FGF-2 antibody. |
| 15 | 18446810 | Endothelial cells were most susceptible to TNFalpha-induced cell death when stimulated with FGF-2 18 h prior to TNFalpha, corresponding to cell entry into S phase of the proliferative cycle. |
| 16 | 21249158 | In an independent experiment, insulin replacement therapy normalized the expression of some proteins (Dbi, Anxa5) while other proteins (Cp, Cryba3, Lgals3, Stat3) were only partially normalized and Fgf2 and Crybb2 expression remained elevated. |
| 17 | 17270172 | Our results suggest that quiescence of small cells correlates with up-regulation of Cdk inhibitors p27(Kip1), p16(INK4a) and p21(CIP1), PTEN, Hep27 and Foxo1a and with down-regulation of c-Myc and the receptors for EGF, FGF2 and HGF. |