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Gene Information
Gene symbol: OLR1
Gene name: oxidized low density lipoprotein (lectin-like) receptor 1
HGNC ID: 8133
Synonyms: LOX-1, SCARE1, CLEC8A
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | AGT | 1 hits |
| 3 | EDN1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | LDLR | 1 hits |
| 6 | MMP9 | 1 hits |
| 7 | NFKB1 | 1 hits |
| 8 | NOS3 | 1 hits |
| 9 | NOX5 | 1 hits |
| 10 | PPARG | 1 hits |
| 11 | SCARB1 | 1 hits |
| 12 | SRA1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21912849 | It has been shown that oxidized low-density lipoprotein (ox-LDL) activates renin-angiotensin system (RAS) and angiotensin II via its type 1 receptor activates ox-LDL receptor LOX-1. |
| 2 | 16007265 | While the physiological role of adipose tissue in cholesterol and oxLDL metabolism remains to be established, the induction of OLR1 is a potential means by which PPARgamma ligands regulate lipid metabolism and insulin sensitivity in adipocytes. |
| 3 | 18801483 | Incubation of HAECs with oxLDL increased LOX-1 expression and enhanced MMP-9 production by these cells. |
| 4 | 18801483 | Induction of LOX-1 and LOX-1-mediated MMP-9 production involved endothelin-1 production and nuclear factor-kappaB activation. |
| 5 | 19736547 | In conclusion, these results support our initial hypothesis and demonstrate that ox-LDL stimulates HSC activation, which is eliminated by curcumin by suppressing lox-1 expression by interrupting Wnt signaling and stimulating PPARgamma activity. |
| 6 | 19878672 | Collectively, our study demonstrates that high glucose-induced oxidative stress via NADPH oxidase activation and this contributed to LOX-1 upregulation and eNOS downregulation in human endothelial cells. |
| 7 | 20385360 | As in atherosclerosis, oxidized LDL and its receptor OLR1 activate the inflammatory pathway through NF-kappaB, leading to transformation. |
| 8 | 19667111 | Pioglitazone downregulated SRA gene expression in adipose tissue of subjects with impaired glucose tolerance and decreased LOX-1 mRNA in vitro. |
| 9 | 19667111 | Macrophage LOX-1 expression was decreased when macrophages were cocultured with adipocytes or when exposed to adipocyte conditioned medium. |
| 10 | 19667111 | Adding adiponectin neutralizing antibody resulted in a 2-fold increase in LOX-1 gene expression demonstrating that adiponectin regulates LOX-1 expression. |
| 11 | 19667111 | Pioglitazone and adiponectin regulate gene expression of SRA and LOX-1, and this may have clinical implications in arresting the untoward sequalae of insulin resistance and diabetes, including accelerated atherosclerosis. |
| 12 | 21650083 | ASX treatment could significantly decrease serum oxLDL and aortic MDA levels, attenuate blunted endothelium-dependent vasodilator responses to ACh, upregulate eNOS expression, and decrease LOX-1 expression. |
| 13 | 21904540 | High glucose elevated LOX1 mRNA, but decreased SR-AI, SR-BI, LDLR, and CD36 mRNA. |
| 14 | 21865331 | In NASH, the LOX-1 polymorphism is associated with liver disease severity and may predispose to CVD through modulation of postprandial small TRLPs and adipokine balance and to diabetes by affecting both insulin secretion and insulin sensitivity. |