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Gene Information

Gene symbol: P4HB

Gene name: prolyl 4-hydroxylase, beta polypeptide

HGNC ID: 8548

Synonyms: PDIA1, PROHB, DSI, GIT, PDI, PO4HB, P4Hbeta

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	INS	1 hits
3	S100A11	1 hits

Related Sentences

#	PMID	Sentence
1	166896	Glutathione-insulin-transhydrogenase is suggested by the appearance of a component that has the same elution volume as the A chain, but the inhibitory effects of trasylol on insulin degradation, as well as qualitative and quantitative similarities with insulin proteases, suggest that a proteolytic similiarities with insulin proteases, suggest that a proteolytic mechanism is involved.
2	17458497	Of special interest among the differentially expressed proteins are those involved in protein folding (Hsp60, protein disulfide isomerase, calreticulin), Ca(2+) binding (calgizzarin, calcyclin and annexin I) and metabolism or signalling (pyruvate kinase, alpha enolase and protein kinase C inhibitor 1).
3	18691554	Using a fluorescent assay based upon a novel pseudo-substrate of PDI, flow cytometry and immunological techniques, we have demonstrated the presence of PDI on the surface of pMP (termed msPDI) and its ability to influence insulin-mediated Akt phosphorylation (Thr308) in 3T3-L1 fibroblasts.
4	18691554	Moreover, pMP are shown to contain catalytically active PDI, capable of both promoting platelet aggregation and disrupting insulin signaling. pMP increased initial rates of aggregation by 4-fold and the pro-aggregatory activity of pMPs could be attenuated with an anti-PDI antibody.