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Gene Information
Gene symbol: PCBP1
Gene name: poly(rC) binding protein 1
HGNC ID: 8647
Synonyms: HNRPE1, hnRNP-E1, HNRPX, hnRNP-X
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | HIF1A | 1 hits |
| 2 | HIF1AN | 1 hits |
| 3 | SETD2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 22055506 | We have identified the iron-dependent prolyl hydroxylases (PHDs) and asparaginyl hydroxylase (FIH1) that modify hypoxia-inducible factor ? (HIF?) as targets of PCBP1. |
| 2 | 22055506 | Depletion of PCBP1 or PCBP2 in cells led to loss of PHD activity, manifested by reduced prolyl hydroxylation of HIF1?, impaired degradation of HIF1? through the VHL/proteasome pathway, and accumulation of active HIF1 transcription factor. |
| 3 | 22055506 | PHD activity was restored in vitro by addition of excess Fe(II), or purified Fe-PCBP1, and PCBP1 bound to PHD2 and FIH1 in vivo. |