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Gene Information

Gene symbol: PCIF1

Gene name: PDX1 C-terminal inhibiting factor 1

HGNC ID: 16200

Synonyms: bA465L10.1

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	PDX1	1 hits

Related Sentences

#	PMID	Sentence
1	20811152	Here, we show that Pcif1 targets Pdx1 for ubiquitination and proteasomal degradation.
2	20811152	These findings indicate that in adult mouse ? cells, Pcif1 limits Pdx1 protein accumulation and thus the expression of insulin and other gene targets important in the maintenance of ? cell mass and function.
3	15121856	Functionally, PCIF1 inhibits PDX-1 transactivation of established target gene promoters in a specific and dose-dependent manner that requires critical amino acids in the PDX-1 C terminus.
4	15121856	PCIF1 is expressed in adult pancreatic insulin-producing beta cells, and overexpression of PCIF1 inhibits the rat insulin 1 and rat insulin 2 promoters in the MIN6 insulinoma beta cell line.
5	17126328	PCIF1 is a TRAF and POZ domain containing nuclear factor that interacts with and inhibits transactivation of pancreatic homeodomain transcription factor PDX-1.
6	17126328	Within PCIF1, the TRAF and POZ domains are both required for physical and functional interaction with the C-terminus of PDX-1, whereas the C-terminal domain of PCIF1 directs its nuclear localization.
7	17126328	Understanding the functional roles of PCIF1 domains may have application to therapeutic beta-cell replacement strategies involving PDX-1 for the treatment of diabetes.