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Gene Information
Gene symbol: PCK1
Gene name: phosphoenolpyruvate carboxykinase 1 (soluble)
HGNC ID: 8724
Synonyms: PEPCK-C
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | NR3C1 | 1 hits |
| 3 | STAT3 | 1 hits |
| 4 | TCF7L2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16100117 | Transient transfections in HepG2 human hepatoma cells showed that glucocorticoid receptor interacts with several non-steroid nuclear receptors, yielding a synergistic response of the PEPCK-C gene promoter to glucocorticoids. |
| 2 | 16282543 | We previously showed that a -232C>G promoter polymorphism within a cis-acting element required for basal and cAMP-mediated PCK1 gene transcription results in loss of negative regulation by insulin, contributing to worsened metabolic control in the context of insulin resistance. |
| 3 | 20484139 | The reduced hepatic glucose output coincided with decreased expression of the gluconeogenic genes G6pc and Pck1 and enhanced hepatic STAT3 phosphorylation and PI3K/Akt signaling in the fasted state. |
| 4 | 20484139 | The increased insulin and IL-6 signaling resulted in enhanced suppression of G6pc and Pck1 mRNA. |
| 5 | 16126724 | In liver, insulin suppresses gluconeogenesis by inhibiting the transcriptions of phosphoenolpyruvate carboxylase (PEPCK) and glucose-6-phosphatase (G6Pase) genes. |
| 6 | 21901280 | Silencing of TCF7L2 induced a marked increase in basal HGP, which was accompanied by significant increases in the expression of the gluconeogenic genes Fbp1, Pck1 and G6pc. |
| 7 | 21901280 | Our results indicate that TCF7L2 binds directly to multiple genes that are important in regulation of glucose metabolism in the liver, including Pck1, Fbp1, Irs1, Irs2, Akt2, Adipor1, Pdk4 and Cpt1a. |