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Gene Information
Gene symbol: PDCD1LG2
Gene name: programmed cell death 1 ligand 2
HGNC ID: 18731
Synonyms: PD-L2, Btdc, PDL2, bA574F11.2, CD273, B7-DC
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CD274 | 1 hits |
| 2 | IFNG | 1 hits |
| 3 | IL2 | 1 hits |
| 4 | PDCD1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16517716 | Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances autoimmune disease in several animal models. |
| 2 | 16517716 | The strain-specific effects of PD-1 ligand blockade did not correlate with the expression of PD-L1 and PD-L2 on dendritic cells and macrophages in lymphoid tissue, or on inflammatory cells in the CNS. |
| 3 | 16606670 | PD-1 has two ligands: PD-1 ligand 1 (PD-L1), which is expressed broadly on hematopoietic and parenchymal cells, including pancreatic islet cells; and PD-L2, which is restricted to macrophages and dendritic cells. |
| 4 | 16606670 | PD-L1 and PD-L2 have overlapping functions in inhibiting interleukin-2 and interferon-gamma production during T cell activation. |
| 5 | 18759926 | Similarly, PD-1 interactions with PD-L1 and PD-L2 downmodulate T-cell immune responses. |