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Gene Information
Gene symbol: PDCD4
Gene name: programmed cell death 4 (neoplastic transformation inhibitor)
HGNC ID: 8763
Synonyms: H731
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | BAX | 1 hits |
| 3 | CHGA | 1 hits |
| 4 | MIRN21 | 1 hits |
| 5 | PCSK1 | 1 hits |
| 6 | PIK3CA | 1 hits |
| 7 | SCG2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18549351 | Using this cell line, we found that suppression of Pdcd4 resulted in an increased release of CgA (chromogranin A) and Sg II (secretogranin II), and was accompanied by an up-regulation of intracellular PC1 (proprotein convertase 1/3). |
| 2 | 18549351 | In accordance with this, inhibition of PI3K activity and, thereby, reduced phosphorylation of Akt was shown to enhance Pdcd4 expression. |
| 3 | 18549351 | Neither the PKC (protein kinase C) signal transduction cascade nor the MAPK (mitogen-activated protein kinase) pathway seemed to play a role in the regulation of CgA and Sg II secretion by Pdcd4. |
| 4 | 18549351 | Our results are of particular interest, as we observed that pioglitazone, an oral medication used in the treatment of Type 2 diabetes, decreased Pdcd4 levels, activated Akt, increased CgA and Sg II secretion and augmented PC1 protein in Bon-1 cells. |
| 5 | 21730150 | In pancreatic ? cells, c-Rel and p65 of the NF-?B family activated the mir21 gene promoter and increased miR-21 RNA levels; miR-21 in turn decreased the level of PDCD4, which is able to induce cell death through the Bax family of apoptotic proteins. |