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Gene Information

Gene symbol: PDK2

Gene name: pyruvate dehydrogenase kinase, isozyme 2

HGNC ID: 8810

Synonyms: PDHK2

Related Genes

#	Gene Symbol	Number of hits
1	INS	1 hits
2	PDK4	1 hits
3	PPARA	1 hits
4	PPARGC1A	1 hits
5	PRL	1 hits
6	SLC2A1	1 hits
7	SLC2A4	1 hits

Related Sentences

#	PMID	Sentence
1	9405294	In contrast with the findings for PDK4, little or no changes in the amounts of PDK1 and PDK2 protein and the abundance of their messages occurred in response to starvation and diabetes.
2	11812733	The decreased level of insulin is likely responsible for the increase in PDK2 mRNA level in starvation and diabetes.
3	12435272	Enhanced expression of PDK4, but not PDK2, occurs in part via a mechanism involving PPAR-alpha.
4	12435272	PPARalpha activation did not influence hepatic PDK2 protein expression in euthyroid rats, suggesting that up-regulation of PDK2 by hyperthyroidism does not involve PPARalpha, but attenuated the effect of hyperthyroidism to increase hepatic PDK2 expression.
5	12435272	The results indicate that hepatic PDK4 up-regulation can be achieved by heterodimerization of either PPARalpha or TR with the RXR receptor and that effects of PPARalpha activation on hepatic PDK2 and PDK4 expression favour a switch towards preferential expression of PDK4.
6	15026305	PDK-2 mRNA level in gastrocnemius muscle was not altered by insulin or FFA (i.e., Intralipid infusion).
7	15967803	We have found that PGC-1alpha will induce the expression of both the PDK2 and PDK4 genes in primary rat hepatocytes and ventricular myocytes.
8	17986714	In glucose transport, PI3Kalpha and PDK2 decreased in IRO subjects, whereas PI3Kgamma, Akt2, GLUT4, and GLUT1 increased.
9	20484462	PRL reduced PDK2 mRNA and protein levels in rat islets and INS-1 cells and PDK4 mRNA in islets; DEX increased PDK2 mRNA in islets and INS-1 cells; this effect was reversed by PRL.