Ignet

Gene Information

Gene symbol: PDK4

Gene name: pyruvate dehydrogenase kinase, isozyme 4

HGNC ID: 8812

Related Genes

#	Gene Symbol	Number of hits
1	AKT1	1 hits
2	ATIC	1 hits
3	CD36	1 hits
4	HNF4A	1 hits
5	INS	1 hits
6	MAPK1	1 hits
7	MAPK14	1 hits
8	MAPK9	1 hits
9	PDHB	1 hits
10	PDHX	1 hits
11	PDK1	1 hits
12	PDK2	1 hits
13	PPARA	1 hits
14	PPARD	1 hits
15	PPARGC1A	1 hits
16	PRKAA1	1 hits
17	TCF7L2	1 hits

Related Sentences

#	PMID	Sentence
1	9405294	Re-feeding of starved rats and insulin treatment of diabetic rats very effectively reversed the increase in PDK4 protein and restored PDK enzyme activity to levels of chow-fed control rats.
2	9405294	In contrast with the findings for PDK4, little or no changes in the amounts of PDK1 and PDK2 protein and the abundance of their messages occurred in response to starvation and diabetes.
3	9405294	The results indicate that control of the amount of PDK4 is important in long-term regulation of the activity of the pyruvate dehydrogenase complex in rat heart.
4	12099888	We evaluated the participation of PPARalpha in regulating PDK4 protein expression in slow oxidative (SO) skeletal muscle (soleus) and fast oxidative-glycolytic (FOG) skeletal muscle (anterior tibialis) containing a high proportion of oxidative fibres.
5	12099888	In the fed state, acute (24 h) activation of PPARalpha by WY14,643 in vivo failed to modify PDK4 protein expression in soleus, but modestly enhanced PDK4 protein expression in anterior tibialis.
6	12435272	Liver contains two pyruvate dehydrogenase kinases (PDKs), namely PDK2 and PDK4, which regulate glucose oxidation through inhibitory phosphorylation of the pyruvate dehydrogenase complex (PDC).
7	12435272	Enhanced expression of PDK4, but not PDK2, occurs in part via a mechanism involving PPAR-alpha.
8	12435272	Administration of the selective PPAR-alpha activator WY14,643 significantly increased PDK4 protein to a similar extent in both control and high-fat-fed rats, but WY14,643 treatment and hyperthyroidism did not have additive effects on hepatic PDK4 protein expression.
9	12435272	The results indicate that hepatic PDK4 up-regulation can be achieved by heterodimerization of either PPARalpha or TR with the RXR receptor and that effects of PPARalpha activation on hepatic PDK2 and PDK4 expression favour a switch towards preferential expression of PDK4.
10	15026305	In contrast, PDK-4 mRNA level was decreased 72% by insulin (P < 0.05), and Intralipid infusion prevented only 20% of the decrease.
11	15026305	PDK-4 protein level was decreased approximately 20% by insulin (P < 0.05), but this effect was not altered by Intralipid infusion.
12	15026305	In conclusion, the present data indicate that insulin had a profound effect to suppress PDK-4 expression in skeletal muscle and that, contrary to previous suggestions, circulating FFA had little impact on PDK-4 mRNA expression, at least within 5 h.
13	15292029	Specific activation of PPAR alpha with WY-14643 rapidly induced pdk4 expression in heart and soleus muscle.
14	15967803	We have found that PGC-1alpha will induce the expression of both the PDK2 and PDK4 genes in primary rat hepatocytes and ventricular myocytes.
15	15967803	Although HNF4 and PGC-1alpha interact to stimulate several genes encoding gluconeogenic enzymes, the induction of PDK4 does not involve interactions of PGC-1alpha with HNF4.
16	15967803	Using the chromatin immunoprecipitation assay, we have demonstrated that HNF4 and PGC-1alpha are associated with the PDK4 gene in vivo.
17	16873695	In the present study, we examined whether insulin's effect on PDK4 expression is impaired in acute insulin-resistant states and, if so, whether this change is accompanied by decreased insulin's effects to stimulate Akt and forkhead box class O (FOXO) 1 phosphorylation.
18	16873695	These data suggest that insulin's effect to suppress PDK4 gene expression in skeletal muscle is impaired in insulin-resistant states, and this may be due to impaired insulin signaling for stimulation of Akt and FOXO1 phosphorylation.
19	17363743	In cardiomyocytes, PKC inhibition attenuated fatty acid-induced increases in the metabolic genes PDK4 and UCP3 and also prevented fatty acid-mediated inhibition of basal and insulin-stimulated glucose oxidation.
20	18308721	Increased fatty acid flux or enforced CD36 expression in C(2)C(12) cells is sufficient to induce FoxO1 and PDK4, whereas CD36 knockdown has opposite effects.
21	18308721	In vivo, CD36 loss blunts fasting induction of FoxO1 and PDK4 and the associated suppression of glucose oxidation.
22	20484462	PRL reduced PDK2 mRNA and protein levels in rat islets and INS-1 cells and PDK4 mRNA in islets; DEX increased PDK2 mRNA in islets and INS-1 cells; this effect was reversed by PRL.
23	20094041	We show for the first time that cellular JNK2- and JNK1/JNK2-deficiency divert glucose from oxidation to glycogenesis due to increased glycogen synthase (GS) activity and induction of Pdk4.
24	20739620	We further postulated that the p38 mitogen-activated protein kinase (MAPK) and 5'-AMP-activated protein kinase (AMPK) signaling pathways would control PDK4 mRNA expression in cultured adipose tissue.
25	20739620	In cultured adipose tissue, epinephrine increased p38 and AMPK signaling; however, the direct activation of AMPK by AICAR or metformin led to reductions in PDK4 mRNA levels.
26	20739620	Reductions in p38 MAPK signaling were associated with decreases in PDK4 mRNA expression.
27	20876715	The decreased glucose oxidation in skeletal muscle is due to decreased pyruvate dehydrogenase (PDH) enzyme activity related, in turn, to increased expression of PDH kinase 4 (pdk4).
28	21162119	Factors that regulate PDK4 mRNA expression include plasma corticosterone, insulin and free fatty acids.
29	18769905	Overexpression of PC in INS-1 cells led to an elevation of insulin secretion and cell proliferation, whereas inhibition of PDH activity by overexpressing Pdk4 in INS-1 cells did not reduce insulin secretion.
30	21901280	Our results indicate that TCF7L2 binds directly to multiple genes that are important in regulation of glucose metabolism in the liver, including Pck1, Fbp1, Irs1, Irs2, Akt2, Adipor1, Pdk4 and Cpt1a.
31	21615395	Results? Basal myotube PPARD expression was closely related to the expression of its target genes PDK4 and ANGPTL4 (P?=?0�0312 and P?=?0�0003, respectively).
32	21615395	Treatment of myotubes with a selective high-affinity PPAR? agonist (GW501516) did not change mean PPARD, but enhanced mean PDK4 and ANGPTL4 expression 13- and 16-fold, respectively (P?
33	21615395	However, GW501516-mediated fold increments in PDK4 and ANGPTL4 expression, reflecting PPAR? responsiveness, were positively associated with donors' insulin sensitivity derived from OGTT (P?=?0�0182 and P?=?0�0231, respectively) and hyperinsulinemic-euglycemic clamp (P?=?0�0046 and P?=?0�0258, respectively).