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Gene Information
Gene symbol: PEA15
Gene name: phosphoprotein enriched in astrocytes 15
HGNC ID: 8822
Synonyms: HMAT1, MAT1, PED, PEA-15, MAT1H, HUMMAT1H
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | EPHB2 | 1 hits |
| 2 | FADD | 1 hits |
| 3 | IL2 | 1 hits |
| 4 | INS | 1 hits |
| 5 | JUN | 1 hits |
| 6 | MAPK8 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17021921 | We conclude that PEA15 overexpression represents a common defect in FDR of patients with type 2 diabetes and is correlated with reduced insulin sensitivity in these individuals. |
| 2 | 20452983 | Here, we demonstrate that PEA-15 is not only pivotal in the activation of the ERK pathway but also modulates JNK (c-Jun N-terminal kinase) signaling. |
| 3 | 20452983 | Upon overexpression of PEA-15 in malignant glioma cells, JNK is potently activated. |
| 4 | 20354143 | PEA-15 also binds to FADD and thereby blocks apoptosis induced by death receptors. |
| 5 | 20354143 | However, PEA-15 deficient T cells had increased CD3/CD28-induced nuclear translocation of ERK and increased activation of IL-2 transcription and secretion in comparison to control wild-type littermates. |
| 6 | 20354143 | In contrast, overexpression of PEA-15 in Jurkat T cells blocked nuclear translocation of ERK and IL-2 transcription. |