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Gene Information
Gene symbol: PHLPP
Gene name: PH domain and leucine rich repeat protein phosphatase
HGNC ID: 20610
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | PRKCA | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18511290 | The Ser/Thr-specific phosphatase PHLPP [pleckstrin homology (PH) domain leucine-rich repeat protein phosphatase] provides 'the brakes' for Akt and protein kinase C (PKC) signaling. |
| 2 | 18511290 | The two isoforms of this recently discovered family, PHLPP1 and PHLPP2, control the amplitude and duration of signaling of Akt and PKC by catalyzing the dephosphorylation of the hydrophobic phosphorylation motif, a C-terminal phosphorylation switch that controls these kinases. |
| 3 | 18511290 | By specifically dephosphorylating the hydrophobic motif, PHLPP controls the degree of agonist-evoked signaling by Akt and the cellular levels of PKC. |