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Gene Information
Gene symbol: PIK3R2
Gene name: phosphoinositide-3-kinase, regulatory subunit 2 (beta)
HGNC ID: 8980
Synonyms: P85B, p85
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PIK3R1 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 14504291 | Pik3r2-/- (p85 beta-/-) cells show a 25% reduction of p85 protein but normal levels of p85-p110 and PI 3-kinase activity, supporting the fact that p85 is more abundant than p110 in wild type. p85 beta-/- cells, however, exhibit significantly increased insulin-induced Akt activation, leading to increased anti-apoptosis. |
| 2 | 14504291 | Indeed, both p85 alpha-/- cells and p85 beta-/- cells exhibit significantly increased insulin-induced glycogen synthase activation. p85 alpha-/- cells show decreased insulin-stimulated Jun N-terminal kinase activity, which is restored by expression of p85 alpha, p85 beta, or a p85 mutant that does not bind to p110, indicating the existence of p85-dependent, but PI 3-kinase-independent, signaling pathway. |