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Gene Information
Gene symbol: PIP
Gene name: prolactin-induced protein
HGNC ID: 8993
Synonyms: GCDFP-15, GCDFP15, GPIP4
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | AKT1 | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | EDN1 | 1 hits |
| 4 | FBXO32 | 1 hits |
| 5 | INS | 1 hits |
| 6 | TRIM63 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17623817 | This antiproteolytic response involved higher PIP(3) and p-Akt levels and a decrease in caspase-3-mediated actin cleavage and activation of the ubiquitin-proteasome system as signified by reduced induction of atrogin-1/MAFbx or MurF1 (muscle-specific RING finger protein 1). |
| 2 | 20197055 | Thus, deletion of p110alpha in liver results in markedly blunted insulin signaling with decreased generation of PIP(3) and loss of insulin activation of Akt, defects that could not be rescued by overexpression of p110beta. |
| 3 | 15919791 | Concomitant with a time-dependent loss of insulin sensitivity, ET-1 caused a parallel reduction in plasma membrane PIP(2). |
| 4 | 15919791 | Despite decreased insulin-stimulated PI 3-kinase activity and PIP(3) generation, ET-1 did not diminish downstream signaling to Akt-2. |
| 5 | 15919791 | Furthermore, addition of exogenous PIP(2), but not PIP(3), restored insulin-regulated GLUT4 translocation and glucose transport impaired by ET-1. |