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Gene Information
Gene symbol: PKN1
Gene name: protein kinase N1
HGNC ID: 9405
Synonyms: DBK, PRK1, PKN, MGC46204, PAK1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDC42 | 1 hits |
| 2 | INS | 1 hits |
| 3 | SLC2A4 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 21969371 | Mimicking this, islets from PAK1(-/-) knock-out mice exhibited profound defects in the second/sustained-phase of insulin secretion. |
| 2 | 21969371 | Analyses of human and mouse islet beta cell signaling revealed PAK1 activation to be 1) dependent upon Cdc42 abundance, 2) crucial for signaling downstream to activate ERK1/2, but 3) dispensable for cofilin phosphorylation. |
| 3 | 21969371 | Exacerbating this, the PAK1(-/-) knock-out mice also exhibited peripheral insulin resistance. |
| 4 | 21969371 | Insulin resistance was coupled to ablation of insulin-stimulated GLUT4 translocation in skeletal muscle from PAK1(-/-) knock-out mice, and in sharp contrast to islet beta cells, skeletal muscle PAK1 loss was underscored by defective cofilin phosphorylation but normal ERK1/2 activation. |