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Gene Information
Gene symbol: PKNOX1
Gene name: PBX/knotted 1 homeobox 1
HGNC ID: 9022
Synonyms: PREP1
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | INS | 1 hits |
| 2 | PTPN6 | 1 hits |
| 3 | SYP | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 18644868 | Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. |
| 2 | 18644868 | We conclude that Prep1 controls insulin sensitivity through the p160-GLUT4 pathway. |
| 3 | 20864515 | Tyrosine phosphorylation of both insulin receptor (IR) and insulin receptor substrate (IRS)1/2 was significantly enhanced in Prep1(i/i) livers accompanied by a specific downregulation of the SYP and SHP1 tyrosine phosphatases. |
| 4 | 20864515 | Prep1 overexpression in HepG2 liver cells upregulated SYP and SHP1 and inhibited insulin-induced IR and IRS1/2 phosphorylation and was accompanied by reduced glycogen content. |
| 5 | 20864515 | Consistently, overexpression of the Prep1 partner Pbx1, but not of p160MBP, mimicked Prep1 effects on tyrosine phosphorylations, glycogen content, and on SYP and SHP1 expression. |
| 6 | 20864515 | In Prep1 overexpressing cells, antisense silencing of SHP1, but not that of SYP, rescued insulin-dependent IR phosphorylation and glycogen accumulation. |
| 7 | 20864515 | Both Prep1 and Pbx1 bind SHP1 promoter at a site located between nucleotides -2,113 and -1,778. |
| 8 | 20864515 | SHP1, a known silencer of insulin signal, is a transcriptional target of Prep1. |
| 9 | 20864515 | In liver, transcriptional activation of SHP1 gene by Prep1 attenuates insulin signal transduction and reduces glucose storage. |