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Gene Information
Gene symbol: PLA2G6
Gene name: phospholipase A2, group VI (cytosolic, calcium-independent)
HGNC ID: 9039
Synonyms: iPLA2, PNPLA9, PARK14, iPLA2beta, NBIA2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | CDKN1A | 1 hits |
| 2 | CYCS | 1 hits |
| 3 | FOXM1 | 1 hits |
| 4 | INS | 1 hits |
| 5 | PANK2 | 1 hits |
| 6 | TP53 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15471944 | Islet Ca2+-independent phospholipase A2 (iPLA2) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues. |
| 2 | 15471944 | However, the significance of iPLA2 signaling in insulin secretion in vivo remains unexplored. |
| 3 | 15471944 | Bromoenol lactone (BEL), a selective inhibitor of iPLA2, inhibited glucose-stimulated insulin secretion from isolated mouse islets; this inhibition was overcome by exogenous arachidonic acid. |
| 4 | 15471944 | These results unambiguously demonstrate that iPLA2 signaling plays an important role in glucose-stimulated insulin secretion under physiological conditions. |
| 5 | 16492706 | Inactivation of iPLA2 failed to arrest p53-deficient HCT cells in the G1 phase and caused massive apoptosis of p21-deficient HCT cells, suggesting that this G1-phase arrest requires activation of p53 and expression of p21cip1. |
| 6 | 16492706 | Furthermore, downregulation of p53 by siRNA in p21-deficient HCT cells reduced the cell death, indicating that inhibition of iPLA2 induced p53-dependent apoptosis in the absence of p21cip1. |
| 7 | 16492706 | Disrupting the G1-phase phospholipid turnover by inhibition of iPLA2 activates the p53-p21cip1 checkpoint mechanism, thereby blocking the entry of G1-phase cells into S phase. |
| 8 | 16728389 | Expression of iPLA2 in INS-1 cells prevented the loss of mitochondrial membrane potential, attenuated the release of cytochrome c, Smac/DIABLO, and apoptosis inducing factor from mitochondria, and reduced mitochondrial reactive oxygen species production. |
| 9 | 16728389 | Finally, we found that STS down-regulated endogenous iPLA2 transcription in both INS-1 and iPLA2-expressing INS-1 cells without affecting the expression of group IV Ca2+-dependent PLA2. |
| 10 | 21496576 | Mutations in pantothenate kinase 2 (PANK2) and phospholipase A2 (PLA2G6) cause recessive, childhood-onset extrapyramidal disorders termed pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD), respectively. |