Ignet

Gene Information

Gene symbol: PNPLA2

Gene name: patatin-like phospholipase domain containing 2

HGNC ID: 30802

Synonyms: desnutrin, TTS-2.2, ATGL, FP17548, iPLA2zeta

Related Genes

#	Gene Symbol	Number of hits
1	ABHD5	1 hits
2	ADIPOQ	1 hits
3	CES1	1 hits
4	CRTC1	1 hits
5	ICAM1	1 hits
6	INS	1 hits
7	INSR	1 hits
8	PLIN	1 hits
9	SERPINF1	1 hits
10	TSC2	1 hits

Related Sentences

#	PMID	Sentence
1	16380488	In 3T3-L1 adipocytes, insulin decreased ATGL and increased adiponutrin expression in a dose- and time-dependent manner, suggesting that insulin directly mediates this nutritional regulation.
2	16380488	In addition, adipose expression of ATGL was increased by insulin deficiency and decreased by insulin replacement in streptozotocin-induced diabetic mice and was increased in fat-specific insulin receptor knockout mice, whereas adiponutrin showed the opposite pattern.
3	16380488	These data suggest that murine ATGL but not adiponutrin contributes to net adipocyte lipolysis and that ATGL and adiponutrin are oppositely regulated by insulin both in vitro and in vivo.
4	18357681	ATGL activity is regulated by CGI-58.
5	18357681	Under basal conditions, interaction of CGI-58 with a lipid droplet associating protein, perilipin, results in an inactivation of ATGL activity.
6	18357681	During PKA-stimulated lipolysis, CGI-58 is released from phosphorylated perilipin and in turn, binds to ATGL.
7	21081832	Cytosolic TG lipase activities were positively correlated with the mRNA levels of CES1 in subcutaneous fat and mesenteric fat, while they were correlated with those of PNPLA2 in omental fat.
8	20068142	In this study, we analyzed the effect of activation and inhibition of the mammalian TORC1 (mTORC1) signaling pathway on the expression of adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), lipolysis, lipogenesis, and lipid storage in different mammalian cells.
9	20068142	Activation of mTORC1 signaling in 3T3-L1 adipocytes by ectopic expression of Rheb inhibits expression of ATGL and HSL at the level of transcription, suppresses lipolysis, increases de novo lipogenesis, and promotes intracellular accumulation of triglycerides.
10	20068142	Inhibition of mTORC1 signaling by rapamycin or by knockdown of raptor stimulates lipolysis primarily via activation of ATGL expression.
11	20068142	Overexpression of ATGL in these cells antagonized the lipogenic effect of TSC2 knockout.
12	21430087	Adiponectin suppressed hormone-sensitive lipase activation without altering adipose triglyceride lipase and CGI-58 expression in adipocytes.
13	21464445	We used ATGL(-/-) mice to determine the role of PEDF in regulating lipid and glucose metabolism.
14	21464445	The results are the first direct demonstration that 1) PEDF influences systemic fatty acid metabolism by promoting lipolysis in an ATGL-dependent manner and reducing fatty acid oxidation and 2) ATGL is required for the negative effects of PEDF on insulin action.
15	21498783	We hypothesized that an imbalance of ATGL relative to HSL (expression or activity) may contribute to DAG accumulation and insulin resistance.
16	21644917	Insulin also suppresses lipolysis by down-regulating the expression of the rate-limiting lipolytic enzyme, adipose triglyceride lipase or ATGL.
17	21828047	We found that ATGL knockdown enhanced monocyte adhesion via increased expression of TNF?-induced intercellular adhesion molecule-1 (ICAM-1).
18	21828047	Next, we determined the pathways (MAPK, PKC, or NF?B) involved in ICAM-1 up-regulation induced by ATGL knockdown.
19	21709540	This work indicates the potential link of ATGL with the pathogenesis of insulin resistance and T2DM.