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Gene Information
Gene symbol: PON3
Gene name: paraoxonase 3
HGNC ID: 9206
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | PON1 | 1 hits |
| 2 | PON2 | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 17900266 | In this investigation, we have examined the role of genetic variation in the PON3 gene in relation to PON1 activity and SLE risk in a biracial sample comprising 377 SLE patients and 482 controls from US whites and blacks. |
| 2 | 17900266 | We genotyped six PON3 tagging single nucleotide polymorphisms (tagSNPs) and examined their associations with PON1 activity, SLE risk, antiphopholipid autoantibodies (APA), lupus nephritis, carotid vascular disease, and inflammation. |
| 3 | 17900266 | With the exception of PON1 activity, no other significant associations were found with PON3 SNPs. |
| 4 | 17900266 | Multiple regression analysis including all six PON3 tagSNPs and PON1/Q192R and L55M SNPs revealed significant association of PON1 activity with 4 SNPs: PON3/A10340C (p < 0.0001), PON3/A2115T (p = 0.002), PON1/L55M (p < 0.0001) and PON1/Q192R (p < 0.0001). |
| 5 | 17900266 | In summary, our new data indicate that genetic variation in the PON3 gene influences serum PON1 activity independently of the known effect of PON1 genetic variation. |
| 6 | 17900266 | To our knowledge, this is the first study reporting the association of the PON3 gene variants with PON1 activity. |
| 7 | 18759523 | However, in contrast to paraoxonase-1 and paraoxonase-3, paraoxonase-2 is not associated with high-density lipoprotein and may only exert its antioxidant function at the cellular level. |
| 8 | 19439227 | In the current study, we analyzed mRNA expression of PON1 as well as other members of the paraoxonase family, PON2 and PON3, in human cataractous lens samples. |
| 9 | 21223581 | Since PON1, PON2 and PON3 share high degree of structural and functional properties, in this study, we examined the role of PON2 genetic variation on serum PON activity, risk of SLE and SLE-related clinical manifestations in a Caucasian case-control sample. |