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Gene Information
Gene symbol: PPARD
Gene name: peroxisome proliferator-activated receptor delta
HGNC ID: 9235
Synonyms: NUC1, NUCII, FAAR, NR1C2
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ANGPTL4 | 1 hits |
| 2 | INS | 1 hits |
| 3 | PDK4 | 1 hits |
| 4 | PPARA | 1 hits |
| 5 | PPARGC1A | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 16187688 | The PPARs act as nutritional lipid sensors and three mammalian PPAR subtypes designated PPARalpha (NR1C1), PPARgamma (NR1C3) and PPARdelta (NR1C2) have been identified. |
| 2 | 16109478 | Recent studies revealed that ligand activation of PPARbeta can induce fatty acid catabolism in skeletal muscle and is associated with improved insulin sensitivity, attenuated weight gain and elevated HDL levels thus demonstrating promising potential for targeting PPARbeta for treating obesity, dyslipidemias and type 2 diabetes. |
| 3 | 17084713 | We also show that PPARbeta stimulates in myocytes the expression of PGC1alpha, a coactivator of various transcription factors, known to play an important role in slow muscle fiber formation. |
| 4 | 17084713 | Moreover, as the PGC1alpha promoter contains a PPAR response element, the effect of PPARbeta on the formation and/or maintenance of slow muscle fibers can be ascribed, at least in part, to a stimulation of PGC1alpha expression at the transcriptional level. |
| 5 | 19074989 | In C2C12 myocytes, knockdown of PPARD, but not of PPARG, blocked LCFA-mediated ANGPTL4 induction, and LCFA treatment resulted in PPAR-delta recruitment to the ANGPTL4 gene. |
| 6 | 16897074 | The aim of this study was to verify whether activation of fatty acid oxidation by PPARbeta agonists in human skeletal muscle cells prepared from type 2 diabetic patients could improve the reduced responses to insulin that characterized this cell model. |
| 7 | 21834910 | Animal studies have shown that the peroxime proliferator-activated receptor delta (PPARD) gene regulates glucose metabolism and insulin sensitivity. |
| 8 | 21615395 | Results? Basal myotube PPARD expression was closely related to the expression of its target genes PDK4 and ANGPTL4 (P?=?0·0312 and P?=?0·0003, respectively). |
| 9 | 21615395 | Basal PPARD, PDK4 and ANGPTL4 expression levels were not associated with donors' insulin sensitivity (P?>?0·2, all). |
| 10 | 21615395 | Treatment of myotubes with a selective high-affinity PPAR? agonist (GW501516) did not change mean PPARD, but enhanced mean PDK4 and ANGPTL4 expression 13- and 16-fold, respectively (P? |