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Gene Information
Gene symbol: PRKD1
Gene name: protein kinase D1
HGNC ID: 9407
Synonyms: PKCM, PKD, PKC-mu
Related Genes
| # | Gene Symbol | Number of hits |
| 1 | ADIPOQ | 1 hits |
| 2 | CASP3 | 1 hits |
| 3 | GRP | 1 hits |
| 4 | INS | 1 hits |
| 5 | LPL | 1 hits |
| 6 | NALCN | 1 hits |
| 7 | PKD1 | 1 hits |
| 8 | SRC | 1 hits |
Related Sentences
| # | PMID | Sentence |
| 1 | 15383372 | Western blot analyses of GIP/Ins cells using antibodies specific for activated and/or phosphorylated forms of PKD and AMPK and one substrate for each kinase revealed that bombesin and PMA, but not nutrients, activated PKC, but not PKD. |
| 2 | 19875622 | In vitro, phosphomimetic PKD colocalized with LPL in the trans-golgi. |
| 3 | 19875622 | Using a caspase inhibitor (Z-DEVD) in D-100 animals, we effectively lowered caspase-3 activity, prevented PKD cleavage, and increased LPL vesicle formation and translocation to the vascular lumen. |
| 4 | 21085109 | Polycystin 1 regulates mTOR activity through different pathways, and TSC intersects with the primary cilium, a crucial cell organelle in the pathogenesis of PKD. |
| 5 | 10751221 | PKCalpha, PKCdelta, PKCepsilon, and PKCmu isoforms found in preglomerular vessels were upregulated by captopril and high insulin doses, respectively, whereas no such regulation occurred in glomeruli. |
| 6 | 21345437 | We therefore investigated the involvement of PKD in regulation of the adiponectin gene expression. |
| 7 | 21345437 | Knockdown of PKD by its siRNA led to the increase in the mRNA and the promoter activity of adiponectin, and resulted in increase of adiponectin secretion and decrease of fat accumulation in cultured cells. |
| 8 | 21345437 | PKD activators decreased expression of the adiponectin gene, and its inhibition by PKD siRNA and by a selective inhibitor Gö6983 canceled this effect. |
| 9 | 21345437 | ChIP analysis demonstrated that inhibition of PKD activity decreased the DNA binding of AP-2? to the adiponectin promoter. |
| 10 | 21345437 | PKD is thus a common modulator of the DNA binding activity of AP-2? and AP-2? through their phosphorylation for negative regulation of the ABCA1 and adiponectin genes expression, respectively. |
| 11 | 21966580 | These include phosphorylation/arrestin-dependent activation of protein kinase D1, Src family kinase-dependent activation of the sodium channel NALCN and the involvement of regulator of G protein signaling (RGS)-4. |